Structure of PDB 1h27 Chain B Binding Site BS01

Receptor Information
>1h27 Chain B (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEE
YKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPE
VAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQP
ANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE
SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLL
NPPETLNL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1h27 Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Resolution2.2 Å
Binding residue
(original residue number in PDB)		M210 L214 W217 E220 R250 L253 Q254 T285
Binding residue
(residue number reindexed from 1)		M36 L40 W43 E46 R76 L79 Q80 T111
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Biological Process
GO:0044772 mitotic cell cycle phase transition

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1h27, PDBe:1h27, PDBj:1h27
PDBsum1h27
PubMed12501191
UniProtP20248|CCNA2_HUMAN Cyclin-A2 (Gene Name=CCNA2)

[Back to BioLiP]