Structure of PDB 1h25 Chain B Binding Site BS01

Receptor Information
>1h25 Chain B (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEE
YKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPE
VAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQP
ANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE
SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLL
NPPETLNL
Ligand information
Receptor-Ligand Complex Structure
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PDB1h25 Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Resolution2.5 Å
Binding residue
(original residue number in PDB)		M210 I213 W217 E224 R250 Q254 I281 T285
Binding residue
(residue number reindexed from 1)		M36 I39 W43 E50 R76 Q80 I107 T111
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Biological Process
GO:0044772 mitotic cell cycle phase transition

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Molecular Function
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Biological Process
External links
PDB RCSB:1h25, PDBe:1h25, PDBj:1h25
PDBsum1h25
PubMed12501191
UniProtP20248|CCNA2_HUMAN Cyclin-A2 (Gene Name=CCNA2)

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