Structure of PDB 1h0g Chain B Binding Site BS01

Receptor Information

>1h0g Chain B (length=497) Species: 615 (Serratia marcescens)

TRKAVIGYYFIPTNQINNYTETDTSVVPFPVSNITPAKAKQLTHINFSFL
DINSNLECAWDPATNDAKARDVVNRLTALKAHNPSLRIMFSIGGWYYSND
LGVSHANYVNAVKTPASRTKFAQSCVRIMKDYGFDGVDIDWEYPQAAEVD
GFIAALQEIRTLLNQQTITDGRQALPYQLTIAGAGGAFFLSRYYSKLAQI
VAPLDYINLMTYDLAGPWEKVTNHQAALFGDAAGPTFYNALREANLGWSW
EELTRAFPSPFSLTVDAAVQQHLMMEGVPSAKIVMGVPFYGRAFKGVSGG
NGGQYSSHSTPGEDPYPSTDYWLVGCEECVRDKDPRIASYRQLEQMLQGN
YGYQRLWNDKTKTPYLYHAQNGLFVTYDDAESFKYKAKYIKQQQLGGVMF
WHLGQDNRNGDLLAALDRYFNAADYDDSQLDMGTGLRYTGVGPGNLPIMT
APAYVPGTTYAQGALVSYQGYVWQTKWGYITSAPGSDSAWLKVGRVA

Ligand information

>1h0g Chain C (length=5) Species: 615 (Serratia marcescens)

RPcHc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1h0g High Resolution Inhibited Complexes of a Chitinase with Natural Product Cyclopentapeptides - Peptide Mimicry of a Carbohydrate Substrate
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): Y10 W97 E144 M212 Y214 D215 W220 Y292 R294 D316 I339 W403
• Binding residue (residue number reindexed from 1): Y8 W95 E142 M210 Y212 D213 W218 Y290 R292 D314 I337 W401

Enzymatic activity

• Catalytic site (original residue number in PDB): D140 D142 E144 Y214
• Catalytic site (residue number reindexed from 1): D138 D140 E142 Y212
• Enzyme Commision number: 3.2.1.14: chitinase.

Gene Ontology

Molecular Function

• GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
• GO:0008061 chitin binding
• GO:0030246 carbohydrate binding

Biological Process

• GO:0005975 carbohydrate metabolic process

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:1h0g, PDBe:1h0g, PDBj:1h0g
• PDBsum: 1h0g
• PubMed: 12093900
• UniProt: P11797|CHIB_SERMA Chitinase B (Gene Name=chiB)