Structure of PDB 1gzr Chain B Binding Site BS01

Receptor Information
>1gzr Chain B (length=61) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSPQTGIVDECCFRSCDLR
RLEMYCAPLKP
Ligand information
Ligand IDC15
InChIInChI=1S/C17H37NO3S/c1-4-5-6-7-8-9-10-11-12-13-15-18(2,3)16-14-17-22(19,20)21/h4-17H2,1-3H3/p+1
InChIKeyIZWSFJTYBVKZNK-UHFFFAOYSA-O
SMILES
SoftwareSMILES
ACDLabs 10.04O=S(=O)(O)CCC[N+](C)(CCCCCCCCCCCC)C
OpenEye OEToolkits 1.5.0CCCCCCCCCCCC[N+](C)(C)CCCS(=O)(=O)O
CACTVS 3.341CCCCCCCCCCCC[N+](C)(C)CCC[S](O)(=O)=O
FormulaC17 H38 N O3 S
NameN-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE
ChEMBL
DrugBankDB02643
ZINCZINC000014880434
PDB chain1gzr Chain B Residue 1067 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1gzr Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
Resolution2.0 Å
Binding residue
(original residue number in PDB)		F25 N26
Binding residue
(residue number reindexed from 1)		F23 N24
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005179 hormone activity
GO:0008083 growth factor activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Molecular Function
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Cellular Component
External links
PDB RCSB:1gzr, PDBe:1gzr, PDBj:1gzr
PDBsum1gzr
PubMed12135360
UniProtP05019|IGF1_HUMAN Insulin-like growth factor I (Gene Name=IGF1)

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