Structure of PDB 1gp7 Chain B Binding Site BS01

Receptor Information
>1gp7 Chain B (length=124) Species: 8665 (Ophiophagus hannah) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLIQFGNMIQCTVPGFLSWIKYADYGCYCGAGGSGTPVDKLDRCCQVHDN
CYTQAQKLPACSSIMDSPYVKIYSYDCSERTVTCKADNDECAAFICNCDR
VAAHCFAASPYNNNNYNIDTTTRC
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1gp7 Chain B Residue 1125 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1gp7 Structure of a Cardiotoxic Phospholipase A(2) from Ophiophagus Hannah with the "Pancreatic Loop"
Resolution2.6 Å
Binding residue
(original residue number in PDB)		Y28 G30 G32 D49
Binding residue
(residue number reindexed from 1)		Y28 G30 G32 D49
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Y28 G30 G32 H48 D49 Y52 Y73 D99
Catalytic site (residue number reindexed from 1) Y28 G30 G32 H48 D49 Y52 Y73 D99
Enzyme Commision number 3.1.1.4: phospholipase A2.
Gene Ontology
Molecular Function
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
Biological Process
GO:0006644 phospholipid metabolic process
GO:0016042 lipid catabolic process
GO:0050482 arachidonate secretion

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1gp7, PDBe:1gp7, PDBj:1gp7
PDBsum1gp7
PubMed12217659
UniProtP80966|PA2A1_OPHHA Acidic phospholipase A2 1

[Back to BioLiP]