Structure of PDB 1gng Chain B Binding Site BS01

Receptor Information

>1gng Chain B (length=356) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCD
SGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVY
LNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI
CHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL
IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT
REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTA
RLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATIL
IPPHAR

Ligand information

>1gng Chain X (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

DPHRLLQQLVLSGNLIKEAVRRLHS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1gng The Structure of Phosphorylated Gsk-3Beta Complexed with a Peptide, Frattide, that Inhibits Beta-Catenin Phosphorylation
Resolution	2.6 Å
Binding residue (original residue number in PDB)	A382 R383
Binding residue (residue number reindexed from 1)	A355 R356

Enzymatic activity

Catalytic site (original residue number in PDB)	D181 K183 N186 D200 S219
Catalytic site (residue number reindexed from 1)	D154 K156 N159 D173 S192
Enzyme Commision number	2.7.11.1: non-specific serine/threonine protein kinase. 2.7.11.26: [tau protein] kinase.

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:1gng, PDBe:1gng, PDBj:1gng
PDBsum	1gng
PubMed	11738041
UniProt	P49841\|GSK3B_HUMAN Glycogen synthase kinase-3 beta (Gene Name=GSK3B)

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