Structure of PDB 1fyt Chain B Binding Site BS01

Receptor Information

>1fyt Chain B (length=179) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDSDVGEYRAVTE
LGRPDAEYWNSQKDLLEQRRAAVDTYCRHNYGVGESFTVQRRVEPKVTVY
PSLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVML
ETVPRSGEVYTCQVEHPSVTSPLTVEWRA

Ligand information

>1fyt Chain C (length=13) Species: 119210 (H3N2 subtype) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

PKYVKQNTLKLAT

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	1fyt Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	W9 L11 F13 Y47 D57 Y60 W61 L67 R71 Y78 H81 N82 V85 F89
Binding residue (residue number reindexed from 1)	W7 L9 F11 Y45 D55 Y58 W59 L65 R69 Y76 H79 N80 V83 F87

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0006955	immune response
GO:0019882	antigen processing and presentation

	Cellular Component
GO:0016020	membrane
GO:0042613	MHC class II protein complex

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:1fyt, PDBe:1fyt, PDBj:1fyt
PDBsum	1fyt
PubMed	11060013
UniProt	P01911\|DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (Gene Name=HLA-DRB1)

[Back to BioLiP]