Structure of PDB 1fpm Chain B Binding Site BS01

Receptor Information
>1fpm Chain B (length=548) Species: 1525 (Moorella thermoacetica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IEIAQAAKMKPVMELARGLGIQEDEVELYGKYKAKISLDVYRRLKDKPDG
KLILVTAITPTPAGEGKTTTSVGLTDALARLGKRVMVCLREPSLGPSFGI
KGGAAGGGYAQVVPMEDINLHFTGDIHAVTYAHNLLAAMVDNHLQQGNVL
NIDPRTITWRRVIDLNDRALRNIVIGLGGKANGVPRETGFDISVASEVMA
CLCLASDLMDLKERFSRIVVGYTYDGKPVTAGDLEAQGSMALLMKDAIKP
NLVQTLENTPAFIHGGPFANIAHGCNSIIATKTALKLADYVVTEAGFGAD
LGAEKFYDVKCRYAGFKPDATVIVATVRALKMHGGVPKSDLATENLEALR
EGFANLEKHIENIGKFGVPAVVAINAFPTDTEAELNLLYELCAKAGAEVA
LSWAKGGEGGLELARKVLQTLESRPSNFHVLYNLDLSIKDKIAKIATEIY
GADGVNYTAEADKAIQRYESLGYGNLPVVMAKTQYSFSDDMTKLGRPRNF
TITVREVRLSAGGRLIVPITGAIMTMPGLPKRPAACNIDIDADGVITG
Ligand information
Ligand IDCS
InChIInChI=1S/Cs/q+1
InChIKeyNCMHKCKGHRPLCM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cs+]
FormulaCs
NameCESIUM ION
ChEMBL
DrugBank
ZINC
PDB chain1fpm Chain B Residue 564 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1fpm Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		E98 P99 I125 N126 L127
Binding residue
(residue number reindexed from 1)		E91 P92 I118 N119 L120
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K74 T76 R97 K108 A276 F304 F384 W412
Catalytic site (residue number reindexed from 1) K67 T69 R90 K101 A269 F297 F377 W403
Enzyme Commision number 6.3.4.3: formate--tetrahydrofolate ligase.
Gene Ontology
Molecular Function
GO:0004329 formate-tetrahydrofolate ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0035999 tetrahydrofolate interconversion

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:1fpm, PDBe:1fpm, PDBj:1fpm
PDBsum1fpm
PubMed11087401
UniProtP21164|FTHS_MOOTH Formate--tetrahydrofolate ligase (Gene Name=fhs)

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