Structure of PDB 1fn9 Chain B Binding Site BS01

Receptor Information
>1fn9 Chain B (length=365) Species: 10891 (Reovirus sp.) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEVCLPNGHQVVDLINNAFEGRVSIYSAQEGWDKTISAQPDMMVCGGAVV
CMHCLGVVGSLQRKLKHLPHHRCNQQIRHQDYVDVQFADRVTAHWKRGML
SFVAQMHEMMNDVSPDDLDRVRTEGGSLVELNWLQVDPNSMFRSIHSSWT
DPLQVVDDLDTKLDQYWTALNLMIDSSDLIPNFMMRDPSHAFNGVKLGGD
ARQTQFSRTFDSRSSLEWGVMVYDYSELEHDPSKGRAYRKELVTPARDFG
HFGLSHYSRATTPILGKMPAVFSGMLTGNCKMYPFIKGTAKLKTVRKLVE
AVNHAWGVEKIRYALGPGGMTGWYNRTMQQAPIVLTPAALTMFPDTIKFG
DLNYPVMIGDPMILG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1fn9 Chain B Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1fn9 Structure of the reovirus outer capsid and dsRNA-binding protein sigma3 at 1.8 A resolution.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		C51 C54 H71 C73
Binding residue
(residue number reindexed from 1)		C51 C54 H71 C73
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005198 structural molecule activity
GO:0030291 protein serine/threonine kinase inhibitor activity
GO:0046872 metal ion binding
Biological Process
GO:0006417 regulation of translation
GO:0019049 virus-mediated perturbation of host defense response
GO:0019058 viral life cycle
GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway
GO:0039580 symbiont-mediated suppression of host PKR/eIFalpha signaling
GO:0052170 symbiont-mediated suppression of host innate immune response
Cellular Component
GO:0019028 viral capsid
GO:0030430 host cell cytoplasm
GO:0039624 viral outer capsid
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1fn9, PDBe:1fn9, PDBj:1fn9
PDBsum1fn9
PubMed11230122
UniProtP03527|SIGM3_REOVD Outer capsid protein sigma-3 (Gene Name=S4)

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