Structure of PDB 1fll Chain B Binding Site BS01

Receptor Information
>1fll Chain B (length=205) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETAS
YNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGD
GMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFK
PDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTS
DLPDP
Ligand information
>1fll Chain Y (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KTAAPVQETLHGSQPVTQEDG
Receptor-Ligand Complex Structure
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PDB1fll Molecular basis for CD40 signaling mediated by TRAF3.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		R393 D399 G400 M401 K403 F410 F448 S456 A467 S468 G469
Binding residue
(residue number reindexed from 1)		R94 D100 G101 M102 K104 F111 F149 S157 A168 S169 G170
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0001817 regulation of cytokine production
GO:0008063 Toll signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0045087 innate immune response
GO:0050688 regulation of defense response to virus

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1fll, PDBe:1fll, PDBj:1fll
PDBsum1fll
PubMed10984535
UniProtQ13114|TRAF3_HUMAN TNF receptor-associated factor 3 (Gene Name=TRAF3)

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