Structure of PDB 1fgg Chain B Binding Site BS01

Receptor Information

>1fgg Chain B (length=246) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MTIYVVTPTYARLVQKAELVRLSQTLSLVPRLHWLLVEDAEGPTPLVSGL
LAASGLLFTHLVVLTPHPRGVEQRNKALDWLRGRGGAVGGEKDPPPPGTQ
GVVYFADDDNTYSRELFEEMRWTRGVSVWPVGLVGGLRFEGPQVQDGRVV
GFHTAWERPFPVDMAGFAVALPLLLDKPNAQFDSTAPRGHLESSLLSHLV
DPKDLEPRAANCTRVLVWHTRTEKPKMKQEEQLQRQGRGSDPAIEV

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

1fgg Chain B Residue 336 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1fgg Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I.
Resolution	2.3 Å
Binding residue (original residue number in PDB)	D196 R310
Binding residue (residue number reindexed from 1)	D109 R221
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	D196 E281
Catalytic site (residue number reindexed from 1)	D109 E192
Enzyme Commision number	2.4.1.135: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase.

Gene Ontology

	Molecular Function
GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:1fgg, PDBe:1fgg, PDBj:1fgg
PDBsum	1fgg
PubMed	10946001
UniProt	O94766\|B3GA3_HUMAN Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (Gene Name=B3GAT3)

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