Structure of PDB 1fa6 Chain B Binding Site BS01

Receptor Information
>1fa6 Chain B (length=128) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRLLHTMLRVGDLQRSIDFYTKVLGMKLLRTSENPEYKYSLAFVGYGPET
EEAVIELTYNWGVDKYELGTAYGHIALSVDNAAEACEKIRQNGGNVTREA
GPVKGGTTVIAFVEDPDGYKIELIEEGN
Ligand information
Ligand IDCO
InChIInChI=1S/Co/q+2
InChIKeyXLJKHNWPARRRJB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Co+2]
CACTVS 3.341[Co++]
FormulaCo
NameCOBALT (II) ION
ChEMBL
DrugBankDB14205
ZINC
PDB chain1fa6 Chain A Residue 1200 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1fa6 Determination of the structure of Escherichia coli glyoxalase I suggests a structural basis for differential metal activation.
Resolution1.9 Å
Binding residue
(original residue number in PDB)
H74 E122
Binding residue
(residue number reindexed from 1)
H74 E122
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H5 E56 H74 E122
Catalytic site (residue number reindexed from 1) H5 E56 H74 E122
Enzyme Commision number 4.4.1.5: lactoylglutathione lyase.
Gene Ontology
Molecular Function
GO:0004462 lactoylglutathione lyase activity
GO:0005515 protein binding
GO:0016151 nickel cation binding
GO:0016829 lyase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0009636 response to toxic substance
GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:1fa6, PDBe:1fa6, PDBj:1fa6
PDBsum1fa6
PubMed10913283
UniProtP0AC81|LGUL_ECOLI Lactoylglutathione lyase (Gene Name=gloA)

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