Structure of PDB 1f9e Chain B Binding Site BS01

Receptor Information
>1f9e Chain B (length=89) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDI
LTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPS
Ligand information
Receptor-Ligand Complex Structure
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PDB1f9e Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		S339 Y340 R341 P343 W348
Binding residue
(residue number reindexed from 1)		S22 Y23 R24 P26 W31
Enzymatic activity
Enzyme Commision number 3.4.22.61: caspase-8.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1f9e, PDBe:1f9e, PDBj:1f9e
PDBsum1f9e
PubMed10964557
UniProtQ14790|CASP8_HUMAN Caspase-8 (Gene Name=CASP8)

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