Structure of PDB 1f1j Chain B Binding Site BS01

Receptor Information
>1f1j Chain B (length=231) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGF
DVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGV
TPIKDLTAHFRGDRSKTLLEKPKLFFIQACRGTELDDGIQKIPVEADFLF
AYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVAR
HFESQSDDPHFHEKKQIPCVVSMLTKELYFS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1f1j The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		R387 H444 Q484 C486 S531 W532 R533 S534 P535 S575 Q576
Binding residue
(residue number reindexed from 1)		R31 H88 Q128 C130 S160 W161 R162 S163 P164 S204 Q205
Enzymatic activity
Catalytic site (original residue number in PDB) G385 V386 H444 G445 C486
Catalytic site (residue number reindexed from 1) G29 V30 H88 G89 C130
Enzyme Commision number 3.4.22.60: caspase-7.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004190 aspartic-type endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0007507 heart development
GO:0009411 response to UV
GO:0016485 protein processing
GO:0030163 protein catabolic process
GO:0042742 defense response to bacterium
GO:0043525 positive regulation of neuron apoptotic process
GO:0044346 fibroblast apoptotic process
GO:0051146 striated muscle cell differentiation
GO:0051402 neuron apoptotic process
GO:0051604 protein maturation
GO:0070227 lymphocyte apoptotic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071887 leukocyte apoptotic process
GO:0072734 cellular response to staurosporine
GO:0097194 execution phase of apoptosis
GO:1905686 positive regulation of plasma membrane repair
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1f1j, PDBe:1f1j, PDBj:1f1j
PDBsum1f1j
PubMed10873833
UniProtP55210|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)

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