Structure of PDB 1ete Chain B Binding Site BS01

Receptor Information
>1ete Chain B (length=134) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TQDCSFQHSPISSDFAVKIRELSDYLLQDYPVTVASNLQDDELCGGLWRL
VLAQRWMERLKTVAGSKMQGLLERVNTEIHFVTKCAFQPPPSCLRFVQTN
ISRLLQETSEQLVALKPWITRQNFSRCLELQCQP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1ete Chain B Residue 1136 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1ete Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		D14 E78
Binding residue
(residue number reindexed from 1)		D14 E78
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005125 cytokine activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:1ete, PDBe:1ete, PDBj:1ete
PDBsum1ete
PubMed10881197
UniProtP49771|FLT3L_HUMAN Fms-related tyrosine kinase 3 ligand (Gene Name=FLT3LG)

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