Structure of PDB 1dqp Chain B Binding Site BS01

Receptor Information
>1dqp Chain B (length=230) Species: 5741 (Giardia intestinalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MICSVTGKPVKDVLSTFFKDRNDVLESEVKKFHLLATFEECKALAADTAR
RMNEYYKDVAEPVTLVALLTGAYLYASLLTVHLTFPYTLHFVKVSSYKGT
RQESVVFDEEDLKQLKEKREVVLIDEYVDSGHTIFSIQEQIKHAKICSCF
VKDVDAIKKHSALADTKMFYGYTPMPKGSWLIGFGLDDNGLRRGWAHLFD
INLSESEVTEFRRRLTEHIKGLNINGVNRY
Ligand information
Ligand IDIMG
InChIInChI=1S/C11H15N5O4/c12-11-15-5-3(1-13-7(5)10(20)16-11)6-9(19)8(18)4(2-17)14-6/h1,4,6,8-9,13-14,17-19H,2H2,(H3,12,15,16,20)/t4-,6+,8-,9+/m1/s1
InChIKeyKBIDJCVAURJXFG-PVEDRDFWSA-N
SMILES
SoftwareSMILES
CACTVS 3.341NC1=Nc2c(c[nH]c2C(=O)N1)[C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1c(c2c([nH]1)C(=O)NC(=N2)N)C3C(C(C(N3)CO)O)O
OpenEye OEToolkits 1.5.0c1c(c2c([nH]1)C(=O)NC(=N2)N)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O
CACTVS 3.341NC1=Nc2c(c[nH]c2C(=O)N1)[CH]3N[CH](CO)[CH](O)[CH]3O
ACDLabs 10.04O=C1NC(=Nc2c1ncc2C3NC(CO)C(O)C3O)N
FormulaC11 H15 N5 O4
Name1,4-DIDEOXY-1,4-IMINO-1-(S)-(9-DEAZAGUANIN-9-YL)-D-RIBITOL;
IMMUCILLIN-G
ChEMBLCHEMBL473922
DrugBankDB02230
ZINCZINC000013525011
PDB chain1dqp Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1dqp Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,).
Resolution1.75 Å
Binding residue
(original residue number in PDB)		D129 W180 L181
Binding residue
(residue number reindexed from 1)		D129 W180 L181
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1dqp, PDBe:1dqp, PDBj:1dqp
PDBsum1dqp
PubMed10841757
UniProtQ24973

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