Structure of PDB 1do5 Chain B Binding Site BS01

Receptor Information
>1do5 Chain B (length=148) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAAVAILGGPGTVQGVVRFLQLTPERCLIEGTIDGLEPGLHGLHVHQYGD
LTNNCNSCGNHFNPDGASHGGPQDSDRHRGDLGNVRADADGRAIFRMEDE
QLKVWDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGIIARSA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1do5 Chain B Residue 29 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1do5 Crystal structure of the second domain of the human copper chaperone for superoxide dismutase.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		H147 H155 H164 D167
Binding residue
(residue number reindexed from 1)		H61 H69 H78 D81
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H130 H132 H147 H155 H164 D167 D201 R224
Catalytic site (residue number reindexed from 1) H44 H46 H61 H69 H78 D81 D115 R138
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006801 superoxide metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1do5, PDBe:1do5, PDBj:1do5
PDBsum1do5
PubMed10677207
UniProtO14618|CCS_HUMAN Copper chaperone for superoxide dismutase (Gene Name=CCS)

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