Structure of PDB 1dks Chain B Binding Site BS01

Receptor Information

>1dks Chain B (length=73) Species: 9606 (Homo sapiens)

KQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQG
WVHYMIHEPEPHILLFRRPLPKK

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 1dks Chain B Residue 300

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1dks Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): R20 Q50 S51 W54
• Binding residue (residue number reindexed from 1): R17 Q47 S48 W51
• Annotation score: 3

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
• GO:0019901 protein kinase binding
• GO:0042393 histone binding
• GO:0043130 ubiquitin binding
• GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0007346 regulation of mitotic cell cycle
• GO:0044772 mitotic cell cycle phase transition
• GO:0048144 fibroblast proliferation
• GO:0051301 cell division

Cellular Component

• GO:0000307 cyclin-dependent protein kinase holoenzyme complex
• GO:0005654 nucleoplasm
• GO:0019005 SCF ubiquitin ligase complex

External links

• PDB: RCSB:1dks, PDBe:1dks, PDBj:1dks
• PDBsum: 1dks
• PubMed: 7791211
• UniProt: P61024|CKS1_HUMAN Cyclin-dependent kinases regulatory subunit 1 (Gene Name=CKS1B)