Structure of PDB 1dew Chain B Binding Site BS01

Receptor Information
>1dew Chain B (length=279) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EGPALYEDPPDHKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAP
DILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCP
LKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWD
EAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQG
FGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSH
SLLPALCDSKIRSKALGSDHCPITLYLAL
Ligand information
Receptor-Ligand Complex Structure
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PDB1dew DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination
Resolution2.65 Å
Binding residue
(original residue number in PDB)		E96 Y128 Y171 N174 R177 D210 N212 N222 N226 F266 T268 M271 K276 V278 W280 H309
Binding residue
(residue number reindexed from 1)		E57 Y89 Y132 N135 R138 D171 N173 N183 N187 F227 T229 M232 K237 V239 W241 H270
Enzymatic activity
Catalytic site (original residue number in PDB) D70 E96 N212 D283 D308
Catalytic site (residue number reindexed from 1) D31 E57 N173 D244 D269
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
3.1.21.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1dew, PDBe:1dew, PDBj:1dew
PDBsum1dew
PubMed10667800
UniProtP27695|APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (Gene Name=APEX1)

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