Structure of PDB 1d6e Chain B Binding Site BS01

Receptor Information

>1d6e Chain B (length=179) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TRPRFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTE
LGRPDAEYWNSQKDLLEQKRAAVDTYCRHNYGVGESFTVQRRVYPEVTVY
PALLVCSVNGFYPGSIEVRWFRNGQEEKTGVVSTGLIQNGDWTFQTLVML
ETVPRSGEVYTCQVEHPSLTSPLTVEWRA

Ligand information

>1d6e Chain D (length=7) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ARGMASG

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1d6e Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures.
Resolution	2.45 Å
Binding residue (original residue number in PDB)	H13 Y30 W61 T77 Y78 H81 N82 V85
Binding residue (residue number reindexed from 1)	H11 Y28 W59 T75 Y76 H79 N80 V83

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0006955	immune response
GO:0019882	antigen processing and presentation

	Cellular Component
GO:0016020	membrane
GO:0042613	MHC class II protein complex

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Biological Process

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Cellular Component

External links

PDB	RCSB:1d6e, PDBe:1d6e, PDBj:1d6e
PDBsum	1d6e
PubMed	10841792
UniProt	P01911\|DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (Gene Name=HLA-DRB1)

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