Structure of PDB 1ckj Chain B Binding Site BS01

Receptor Information

>1ckj Chain B (length=293) Species: 10116 (Rattus norvegicus)

MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLH
IESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKF
SLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDF
GLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLG
YVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFAT
YLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNML

Ligand information

• Ligand ID: WO4
• InChI: InChI=1S/4O.W/q;;2*-1;
• InChIKey: PBYZMCDFOULPGH-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: [O-][W](=O)(=O)[O-]
  ACDLabs 10.04
  CACTVS 3.341: [O-][W]([O-])(=O)=O
• Formula: O4 W
• Name: TUNGSTATE(VI)ION
• PDB chain: 1ckj Chain B Residue 400

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1ckj Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition.
• Resolution: 2.46 Å
• Binding residue (original residue number in PDB): R183 Q219
• Binding residue (residue number reindexed from 1): R178 Q214
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D131 K133
• Catalytic site (residue number reindexed from 1): D128 K130
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.
  2.7.11.26: [tau protein] kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:1ckj, PDBe:1ckj, PDBj:1ckj
• PDBsum: 1ckj
• PubMed: 8648628
• UniProt: Q06486|KC1D_RAT Casein kinase I isoform delta (Gene Name=Csnk1d)