Structure of PDB 1c0e Chain B Binding Site BS01

Receptor Information

>1c0e Chain B (length=154) Species: 9913 (Bos taurus)

VTKSVLFVCLGNICRAPIAEAVFRKLVTDQNISDNWVIDSGAVSDWNVGR
SPDPRAVSCLRNHGINTAHKARQVTKEDFVTFDYILCMDESNLRDLNRKS
NQVKNCRAKIELLGSYDPQKQLIIEDPYYGNDADFETVYQQCVRCCRAFL
EKVR

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 1c0e Chain B Residue 358

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1c0e The structure of the bovine protein tyrosine phosphatase dimer reveals a potential self-regulation mechanism.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): C212 L213 G214 N215 I216 C217 R218 D329
• Binding residue (residue number reindexed from 1): C9 L10 G11 N12 I13 C14 R15 D126
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): C212 N215 C217 R218 A219 D329
• Catalytic site (residue number reindexed from 1): C9 N12 C14 R15 A16 D126
• Enzyme Commision number: 3.1.3.2: acid phosphatase.
  3.1.3.48: protein-tyrosine-phosphatase.

Gene Ontology

Molecular Function

• GO:0003993 acid phosphatase activity
• GO:0004721 phosphoprotein phosphatase activity
• GO:0004725 protein tyrosine phosphatase activity
• GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
• GO:0016791 phosphatase activity

Biological Process

• GO:0006470 protein dephosphorylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1c0e, PDBe:1c0e, PDBj:1c0e
• PDBsum: 1c0e
• PubMed: 10512620
• UniProt: P11064|PPAC_BOVIN Low molecular weight phosphotyrosine protein phosphatase (Gene Name=ACP1)