Structure of PDB 1bzl Chain B Binding Site BS01
Receptor Information
>1bzl Chain B (length=483) Species:
5693
(Trypanosoma cruzi) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
IFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCV
NVGCVPKKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKNLIAVKDEAV
LNINKSYDEMFRDTEGLEFFLGWGSLESKNVVNVRESADPASAVKERLET
EHILLASGSWPHMPNIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEF
AGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELTKQLTANGIQILTKE
NPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNAGVMI
KNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGTTP
RKTDHTRVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHKVS
GSKYKTFVAKIITNHSDGTVLGVHLLGDNAPEIIQGIGICLKLNAKISDF
YNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKP
Ligand information
Ligand ID
GCG
InChI
InChI=1S/C27H49N9O10S2/c28-16(26(43)44)4-6-20(37)35-18(14-47)24(41)33-12-22(39)31-10-2-1-8-30-9-3-11-32-23(40)13-34-25(42)19(15-48)36-21(38)7-5-17(29)27(45)46/h16-19,30,47-48H,1-15,28-29H2,(H,31,39)(H,32,40)(H,33,41)(H,34,42)(H,35,37)(H,36,38)(H,43,44)(H,45,46)/t16-,17-,18-,19-/m0/s1
InChIKey
PHDOXVGRXXAYEB-VJANTYMQSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.5.0
C(CCNC(=O)CNC(=O)C(CS)NC(=O)CCC(C(=O)O)N)CNCCCNC(=O)CNC(=O)C(CS)NC(=O)CCC(C(=O)O)N
OpenEye OEToolkits 1.5.0
C(CCNC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@@H](C(=O)O)N)CNCCCNC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@@H](C(=O)O)N
CACTVS 3.341
N[CH](CCC(=O)N[CH](CS)C(=O)NCC(=O)NCCCCNCCCNC(=O)CNC(=O)[CH](CS)NC(=O)CC[CH](N)C(O)=O)C(O)=O
ACDLabs 10.04
O=C(NCC(=O)NCCCNCCCCNC(=O)CNC(=O)C(NC(=O)CCC(C(=O)O)N)CS)C(NC(=O)CCC(C(=O)O)N)CS
CACTVS 3.341
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)NCCCCNCCCNC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O)C(O)=O
Formula
C27 H49 N9 O10 S2
Name
BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE;
TRYPANOTHIONE
ChEMBL
DrugBank
DB03470
ZINC
ZINC000008217540
PDB chain
1bzl Chain A Residue 603 [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
1bzl
Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors.
Resolution
2.4 Å
Binding residue
(original residue number in PDB)
F396 H461 T463 E466
Binding residue
(residue number reindexed from 1)
F392 H457 T459 E462
Annotation score
5
Enzymatic activity
Catalytic site (original residue number in PDB)
S15 L49 C53 C58 K61 R86 T87 F199 E203 I339 G459 H461 E466 E485 K486
Catalytic site (residue number reindexed from 1)
S11 L45 C49 C54 K57 R82 T83 F195 E199 I335 G455 H457 E462 E481 K482
Enzyme Commision number
1.8.1.12
: trypanothione-disulfide reductase.
Gene Ontology
Molecular Function
GO:0004362
glutathione-disulfide reductase (NADPH) activity
GO:0015036
disulfide oxidoreductase activity
GO:0015042
trypanothione-disulfide reductase (NADPH) activity
GO:0016491
oxidoreductase activity
GO:0016668
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660
flavin adenine dinucleotide binding
Biological Process
GO:0006749
glutathione metabolic process
GO:0034599
cellular response to oxidative stress
GO:0045454
cell redox homeostasis
GO:0098869
cellular oxidant detoxification
Cellular Component
GO:0005737
cytoplasm
GO:0005739
mitochondrion
GO:0005829
cytosol
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1bzl
,
PDBe:1bzl
,
PDBj:1bzl
PDBsum
1bzl
PubMed
10368274
UniProt
P28593
|TYTR_TRYCR Trypanothione reductase (Gene Name=TPR)
[
Back to BioLiP
]