Structure of PDB 1brw Chain B Binding Site BS01
Receptor Information
>1brw Chain B (length=433) Species:
1422
(Geobacillus stearothermophilus) [
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MRMVDLIAKKRDGKALTKEEIEWIVRGYTNGDIPDYQMSALAMAIYFRGM
TEEETAALTMAMVQSGEMLDLSSIRGVKVDKHSTGGVGDTTTLVLGPLVA
SVGVPVAKMSGRGLGHTGGTIDKLESVPGFHVEISKDEFIRLVNENGIAI
IGQTGDLTPADKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDV
KTGAGAFMKKLDEARRLARVMVDIGKRVGRRTMAVISDMSQPLGYAVGNA
LEVKEAIETLKGNGPHDLTELCLTLGSHMVYLAEKAPSLDEARRLLEEAI
RSGAAIAAFKTFLAAQGGDASVVDDLDKLPKAAYTSTVTAAADGYVAEMA
ADDIGTAAMWLGAGRAKKEDVIDLAVGIVLHKKIGDRVQKGEALATIHSN
RPDVLDVKEKIEAAIRLSPQPVARPPLIYETIV
Ligand information
Ligand ID
PO4
InChI
InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKey
NBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
Software
SMILES
CACTVS 3.341
[O-][P]([O-])([O-])=O
ACDLabs 10.04
[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0
[O-]P(=O)([O-])[O-]
Formula
O4 P
Name
PHOSPHATE ION
ChEMBL
DrugBank
DB14523
ZINC
PDB chain
1brw Chain B Residue 2002 [
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Receptor-Ligand Complex Structure
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PDB
1brw
The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation.
Resolution
2.1 Å
Binding residue
(original residue number in PDB)
H1082 S1083 T1092 K1108 S1110 T1120
Binding residue
(residue number reindexed from 1)
H82 S83 T92 K108 S110 T120
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
D1080 K1081 H1082 S1083 T1120 D1161 R1168 S1183 K1187 K1188
Catalytic site (residue number reindexed from 1)
D80 K81 H82 S83 T120 D161 R168 S183 K187 K188
Enzyme Commision number
2.4.2.2
: pyrimidine-nucleoside phosphorylase.
Gene Ontology
Molecular Function
GO:0004645
1,4-alpha-oligoglucan phosphorylase activity
GO:0004850
uridine phosphorylase activity
GO:0009032
thymidine phosphorylase activity
GO:0016154
pyrimidine-nucleoside phosphorylase activity
GO:0016757
glycosyltransferase activity
GO:0016763
pentosyltransferase activity
GO:0046872
metal ion binding
GO:0047847
deoxyuridine phosphorylase activity
Biological Process
GO:0006206
pyrimidine nucleobase metabolic process
GO:0006213
pyrimidine nucleoside metabolic process
Cellular Component
GO:0005829
cytosol
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Molecular Function
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Cellular Component
External links
PDB
RCSB:1brw
,
PDBe:1brw
,
PDBj:1brw
PDBsum
1brw
PubMed
9817849
UniProt
P77836
|PDP_GEOSE Pyrimidine-nucleoside phosphorylase (Gene Name=pdp)
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