Structure of PDB 1beh Chain B Binding Site BS01

Receptor Information
>1beh Chain B (length=183) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLSKWSGPLSLQEVDEQPQHPLHVTYAGAAVDELGKVLTPTQVKNRPTSI
SWDGLDSGKLYTLVLTDPDAPSRKDPKYREWHHFLVVNMKGNDISSGTVL
SDYVGSGPPKGTGLHRYVWLVYEQDRPLKCDEPILSNRSGDHRGKFKVAS
FRKKYELRAPVAGTCYQAEWDDYVPKLYEQLSG
Ligand information
Ligand IDCAC
InChIInChI=1S/C2H7AsO2/c1-3(2,4)5/h1-2H3,(H,4,5)/p-1
InChIKeyOGGXGZAMXPVRFZ-UHFFFAOYSA-M
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C[As](=O)(C)[O-]
CACTVS 3.370C[As](C)([O-])=O
ACDLabs 12.01[O-][As](=O)(C)C
FormulaC2 H6 As O2
NameCACODYLATE ION;
dimethylarsinate
ChEMBL
DrugBank
ZINC
PDB chain1beh Chain B Residue 188 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1beh Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		D70 W84 H86 G110 H118 Y120
Binding residue
(residue number reindexed from 1)		D67 W81 H83 G107 H115 Y117
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008289 lipid binding
GO:0008429 phosphatidylethanolamine binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
Biological Process
GO:0010466 negative regulation of peptidase activity
GO:0043409 negative regulation of MAPK cascade
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1beh, PDBe:1beh, PDBj:1beh
PDBsum1beh
PubMed9782050
UniProtP30086|PEBP1_HUMAN Phosphatidylethanolamine-binding protein 1 (Gene Name=PEBP1)

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