Structure of PDB 1b7x Chain B Binding Site BS01

Receptor Information
>1b7x Chain B (length=246) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRYERNIEKISMLEKIYIHPRYNWRENLDRDIAL
MKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPSVL
QVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFV
MKSPFNNRWYQMGIVSWGEGCDRDGKIGFYTHVFRLKKWIQKVIDQ
Ligand information
>1b7x Chain A (length=26) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKSLEDKTERELLESY
Receptor-Ligand Complex Structure
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PDB1b7x Unexpected crucial role of residue 225 in serine proteases.
Resolution2.1 Å
Binding residue
(original residue number in PDB)
D21 E23 M26 P28 W29 D116 H119 P120 C122 L129C Y134 K135 R137 N159 K202 P204 N205 R206 W207
Binding residue
(residue number reindexed from 1)
D6 E8 M11 P13 W14 D111 H114 P115 C117 L127 Y132 K133 R135 N154 K202 P204 N207 R208 W209
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D97 E192 G193 D194 S195 G196
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function

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Biological Process
External links
PDB RCSB:1b7x, PDBe:1b7x, PDBj:1b7x
PDBsum1b7x
PubMed10051558
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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