Structure of PDB 1b66 Chain B Binding Site BS01

Receptor Information

>1b66 Chain B (length=138) Species: 10117 (Rattus rattus)

LRRRARLSRLVSFSASHRLHSPSLSAEENLKVFGKCNNPNGHGHNYKVVV
TIHGEIDPVTGMVMNLTDLKEYMEEAIMKPLDHKNLDLDVPYFADVVSTT
ENVAVYIWENLQRLLPVGALYKVKVYETDNNIVVYKGE

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 1b66 Chain B Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1b66 Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): H23 H48 H50
• Binding residue (residue number reindexed from 1): H17 H42 H44
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H23 C42 H48 H50 D88 H89 E133
• Catalytic site (residue number reindexed from 1): H17 C36 H42 H44 D82 H83 E127
• Enzyme Commision number: 4.2.3.12: 6-pyruvoyltetrahydropterin synthase.

Gene Ontology

Molecular Function

• GO:0003874 6-pyruvoyltetrahydropterin synthase activity
• GO:0016829 lyase activity
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006729 tetrahydrobiopterin biosynthetic process

Cellular Component

• GO:0005739 mitochondrion

External links

• PDB: RCSB:1b66, PDBe:1b66, PDBj:1b66
• PDBsum: 1b66
• PubMed: 10024455
• UniProt: P27213|PTPS_RAT 6-pyruvoyl tetrahydrobiopterin synthase (Gene Name=Pts)