Structure of PDB 1au1 Chain B Binding Site BS01
Receptor Information
>1au1 Chain B (length=163) Species:
9606
(Homo sapiens) [
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MSYNLLGFLQRSSNFQCQKLLWQLNGRCLKDRMNFDIPEEIKQLQQFQKE
DAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLE
EKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRN
FYFINRLTGYLRN
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
1au1 Chain B Residue 169 [
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Receptor-Ligand Complex Structure
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PDB
1au1
The crystal structure of human interferon beta at 2.2-A resolution.
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
H93 H97
Binding residue
(residue number reindexed from 1)
H90 H94
Annotation score
1
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0005125
cytokine activity
GO:0005126
cytokine receptor binding
GO:0005132
type I interferon receptor binding
GO:0005515
protein binding
GO:0008811
chloramphenicol O-acetyltransferase activity
Biological Process
GO:0002250
adaptive immune response
GO:0002286
T cell activation involved in immune response
GO:0002312
B cell activation involved in immune response
GO:0002323
natural killer cell activation involved in immune response
GO:0006952
defense response
GO:0006959
humoral immune response
GO:0007166
cell surface receptor signaling pathway
GO:0007259
cell surface receptor signaling pathway via JAK-STAT
GO:0009615
response to virus
GO:0010508
positive regulation of autophagy
GO:0019221
cytokine-mediated signaling pathway
GO:0030101
natural killer cell activation
GO:0030183
B cell differentiation
GO:0033141
positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0035458
cellular response to interferon-beta
GO:0042100
B cell proliferation
GO:0043330
response to exogenous dsRNA
GO:0045071
negative regulation of viral genome replication
GO:0045087
innate immune response
GO:0045089
positive regulation of innate immune response
GO:0045343
regulation of MHC class I biosynthetic process
GO:0045581
negative regulation of T cell differentiation
GO:0045944
positive regulation of transcription by RNA polymerase II
GO:0051607
defense response to virus
GO:0060337
type I interferon-mediated signaling pathway
GO:0070050
neuron cellular homeostasis
GO:0071360
cellular response to exogenous dsRNA
GO:0098586
cellular response to virus
GO:0140123
negative regulation of Lewy body formation
GO:2000552
negative regulation of T-helper 2 cell cytokine production
GO:2001235
positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005576
extracellular region
GO:0005615
extracellular space
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1au1
,
PDBe:1au1
,
PDBj:1au1
PDBsum
1au1
PubMed
9342320
UniProt
P01574
|IFNB_HUMAN Interferon beta (Gene Name=IFNB1)
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