Structure of PDB 1adj Chain B Binding Site BS01
Receptor Information
>1adj Chain B (length=420) Species:
274
(Thermus thermophilus) [
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TARAVRGTKDLFGKELRMHQRIVATARKVLEAAGALELVTPIFEETQVFE
KGVGAATDIVRKEMFTFQDRGGRSLTLRPEGTAAMVRAYLEHGMKVWPQP
VRLWMAGPMFRAERPQKGRYRQFHQVNYEALGSENPILDAEAVVLLYECL
KELGLRRLKVKLSSVGDPEDRARYNAYLREVLSPHREALSEDSKERLEEN
PMRILDSKSERDQALLKELGVRPMLDFLGEEARAHLKEVERHLERLSVPY
ELEPALVRGLDYYVRTAFEVHHEEIGAQSALGGGGRYDGLSELLGGPRVP
GVGFAFGVERVALALEAEGFGLPEEKGPDLYLIPLTEEAVAEAFYLAEAL
RPRLRAEYALAPRKPAKGLEEALKRGAAFAGFLGEDELRAGEVTLKRLAT
GEQVRLSREEVPGYLLQALG
Ligand information
Ligand ID
HIS
InChI
InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/p+1/t5-/m0/s1
InChIKey
HNDVDQJCIGZPNO-YFKPBYRVSA-O
SMILES
Software
SMILES
OpenEye OEToolkits 1.5.0
c1c([nH+]c[nH]1)CC(C(=O)O)N
CACTVS 3.341
N[CH](Cc1c[nH]c[nH+]1)C(O)=O
CACTVS 3.341
N[C@@H](Cc1c[nH]c[nH+]1)C(O)=O
ACDLabs 10.04
O=C(O)C(N)Cc1cnc[nH+]1
OpenEye OEToolkits 1.5.0
c1c([nH+]c[nH]1)C[C@@H](C(=O)O)N
Formula
C6 H10 N3 O2
Name
HISTIDINE
ChEMBL
DrugBank
ZINC
PDB chain
1adj Chain B Residue 423 [
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Receptor-Ligand Complex Structure
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PDB
1adj
Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase.
Resolution
2.7 Å
Binding residue
(original residue number in PDB)
E81 T83 E130 Y263 Y264 G304 F305
Binding residue
(residue number reindexed from 1)
E80 T82 E129 Y262 Y263 G303 F304
Annotation score
5
Enzymatic activity
Enzyme Commision number
6.1.1.21
: histidine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0004812
aminoacyl-tRNA ligase activity
GO:0004821
histidine-tRNA ligase activity
GO:0005524
ATP binding
Biological Process
GO:0006412
translation
GO:0006427
histidyl-tRNA aminoacylation
Cellular Component
GO:0005737
cytoplasm
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1adj
,
PDBe:1adj
,
PDBj:1adj
PDBsum
1adj
PubMed
9115984
UniProt
P56194
|SYH_THET8 Histidine--tRNA ligase (Gene Name=hisS)
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