Structure of PDB 1a2v Chain B Binding Site BS01

Receptor Information

>1a2v Chain B (length=655)

PARPAHPLDPLSTAEIKAATNTVKSYFAGKKISFNTVTLREPARKAYIQW
KEQGGPLPPRLAYYVILEAGKPGVKEGLVDLASLSVIETRALETVQPILT
VEDLCSTEEVIRNDPAVIEQCVLSGIPANEMHKVYCDPWTIGYDERWGTG
KRLQQALVYYRSDEDDSQYSHPLDFCPIVDTEEKKVIFIDIPNRRRKVSK
HKHANFYPKHMIEKVGAMRPEAPPINVTQPEGVSFKMTGNVMEWSNFKFH
IGFNYREGIVLSDVSYNDHGNVRPIFHRISLSEMIVPYGSPEFPHQRKHA
LDIGEYGAGYMTNPLSLGCDCKGVIHYLDAHFSDRAGDPITVKNAVCIHE
EDDGLLFKHSDFRDNFATSLVTRATKLVVSQIFTAANYEYCLYWVFMQDG
AIRLDIRLTGILNTYILGDDEEAGPWGTRVYPNVNAHNHQHLFSLRIDPR
IDGDGNSAAACDAKSSPYPLGSPENMYGNAFYSEKTTFKTVKDSLTNYES
ATGRSWDIFNPNKVNPYSGKPPSYKLVSTQCPPLLAKEGSLVAKRAPWAS
HSVNVVPYKDNRLYPSGDHVPQWSGDGVRGMREWIGDGSENIDNTDILFF
HTFGITHFPAPEDFPLMPAEPITLMLRPRHFFTENPGLDIQPSYAMTTSE
AKRAV

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 1a2v Chain B Residue 1

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1a2v Crystallographic study of yeast copper amine oxidase.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): H456 H458 H624
• Binding residue (residue number reindexed from 1): H439 H441 H607
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.4.3.21: primary-amine oxidase.

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0008131 primary methylamine oxidase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0048038 quinone binding
• GO:0052595 aliphatic amine oxidase activity

Biological Process

• GO:0009308 amine metabolic process

Cellular Component

• GO:0005777 peroxisome

External links

• PDB: RCSB:1a2v, PDBe:1a2v, PDBj:1a2v
• PDBsum: 1a2v
• PubMed: 15299901
• UniProt: P12807|AMO_PICAN Peroxisomal primary amine oxidase (Gene Name=AMO)