Structure of PDB 9f1c Chain Aw Binding Site BS01

Receptor Information

>9f1c Chain Aw (length=141) Species: 9986 (Oryctolagus cuniculus)

GKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIV
LEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVL
VAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPR

Ligand information

>9f1c Chain A2 (length=1770)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuugguga
cucuagauaaccucgggccgaucgcacgcccuccguggcggcgacgaccc
auucgaacgucugcccuaucaacuuucgaugguagucgccgugccuacca
uggugaccacgggugacggggaaucaggguucgauuccggagagggagcc
ugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuaccc
acucccgacccggggagguagugacgaaaaauaacaauacaggacucuuu
cgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauc
cauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaau
agcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuuggg
agcgggcggccgcccguccccgccucucggcgccccggggcccgaagcgu
uuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggaua
ccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuu
cggaacugaggccaugauuaagagggacggccgggggcauucguauugcg
ccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaag
cauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucga
agacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcg
augcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaa
agucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaagga
auugacggaagggcaccaccaggaguggagccugcggcuuaauuugacuc
aacacgggaaaccucacccggcccggacacggacaggauugacagauuga
uagcucuuucucgauuccgugggugguggugcauggccguucuuaguugg
uggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugc
uaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagag
ggacaaguggcguucagccacccgagauugagcaauaacaggucugugau
gcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgu
gugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgu
gauggggaucggggauugcaauuauuccccaugaacgaggaauucccagu
aagugcgggucauaagcuugcguugauuaagucccugcccuuuguacaca
ccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucgg
ccccgccggggucggcccacggcccuggcggagcgcugagaagacggucg
aacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggug
aaccugcggaaggaucauua

...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[[[.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>>[[..(((((.....<<<<<<<<<<<<<..>>>>.......<....
..>..)))))......]]...<<<<.<<<<......>>>>>>>>.]].]]
]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>
>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<.
.........>>>.>>.<.<<....>>.>...]]]]]].........<<<.
...<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<...
.>>>..>>>>>>.>>>......<<..<...........>..>>.......
..<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>.
.)))))).]]]............{{.......{{...[[[.[[....<<<
.<<<<<<<..>>>>>>>.>>><<...<<<..<<<<<>>>>>.>>>.>>..
<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>
......>.>>>..>>>........{.[[.(((((((.....>>>>>>>>>
.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<<
<<<...<<<......>>>......>>>>>>>>..>>.......<<....>
>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<..
.<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<.
.<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>..
.>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]
..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<....
....>>..........<<<<<.<....<<<<<<.......<<.<<<....
....>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<
<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<
<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..
>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>
>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<........
<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>..
....<.....<<<<<..........>>>>>.....>.....>>>>>....
.<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>..
..<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<
<<<<<<<<<<<<<<.....>>>>>>>>>>>>.>.>>>>>...>>.>>>>.
.>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<..
..>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 9f1c NAC guides a ribosomal multienzyme complex for nascent protein processing.
• Resolution: 3.78 Å
• Binding residue (original residue number in PDB): G2 K3 C4 R5 G6 R8 T9 R11 K12 H16 R17 R18 Q20 W22 H23 D24 K25 K28 L36 S45 H46 K48 K60 N63 S64 A65 I66 R67 K68 N87 D88 G104 G106 R107 K108 H110 V112 G113 D114 I115 R119 K121 S129 K138
• Binding residue (residue number reindexed from 1): G1 K2 C3 R4 G5 R7 T8 R10 K11 H15 R16 R17 Q19 W21 H22 D23 K24 K27 L35 S44 H45 K47 K59 N62 S63 A64 I65 R66 K67 N86 D87 G103 G105 R106 K107 H109 V111 G112 D113 I114 R118 K120 S128 K137

External links

• PDB: RCSB:9f1c, PDBe:9f1c, PDBj:9f1c
• PDBsum: 9f1c
• PubMed: 39169182
• UniProt: G1SZ47|RS23_RABIT Small ribosomal subunit protein uS12 (Gene Name=RPS23)