Structure of PDB 7uio Chain Aq Binding Site BS01

Receptor Information
>7uio Chain Aq (length=515) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PHEIYGSMPLEQLIPIILRQRGPGFKFVDLNEKELQNEIKQLGSQEQFVK
RRRDMLEHINLAMNESSLALEFVSLLLSSVKESTGMSSMSPFLRKVVKPS
SLNSDKIPYVAPTKKEYIELDILNKGWKLQSLNESKDLLRASFNKLSSIL
QNEHDYWNKIMQSISNKDVIFKIRDRTSGQKLLAIKYGYEDSGSTYKHDR
GIANIRNNIESQNLDLIPHSSSVFKGTDFVHSVKKFLRVRIFTKIESEDD
YILSGESVMDRDSESEEAETKDIRKQIQLLKKIIFEKELMYQIKKECALL
ISYGVSIENENKVIIELPNEKFEIELLSLDLPKINDKRANLMLVMLRLLL
VVIFKKTLRSRISSPHGLINLNVDDDILIIRPILGKVRFANYKLLLKKII
KDYVLDIVPGSSITETEVEDDENITKLNKEIRAFDKLLNIPRRELKINLP
LTEHKSPNLSLMLESPNYCNALIHIKFSAGTEANAVSFDTTFSDFKEVED
FLHFIVAEYIQQKKV
Ligand information
>7uio Chain Az (length=25) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PSYSPTSPSYSPTSPSYSPTSPSYS
Receptor-Ligand Complex Structure
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PDB7uio Structural basis of a transcription pre-initiation complex on a divergent promoter.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		N216 S219 E223 S242 F244 L245
Binding residue
(residue number reindexed from 1)		N64 S67 E71 S90 F92 L93
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001139 RNA polymerase II complex recruiting activity
GO:0003712 transcription coregulator activity
GO:0005515 protein binding
GO:0140297 DNA-binding transcription factor binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0034605 cellular response to heat
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0016592 mediator complex
GO:0070847 core mediator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uio, PDBe:7uio, PDBj:7uio
PDBsum7uio
PubMed36731470
UniProtP32569|MED17_YEAST Mediator of RNA polymerase II transcription subunit 17 (Gene Name=SRB4)

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