Structure of PDB 8btk Chain Af Binding Site BS01

Receptor Information
>8btk Chain Af (length=237) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVV
RISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGC
IVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKE
DDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTK
KNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSL
Ligand information
>8btk Chain A2 (length=1770) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuugguga
cucuagauaaccucgggccgaucgcacgcccuccguggcggcgacgaccc
auucgaacgucugcccuaucaacuuucgaugguagucgccgugccuacca
uggugaccacgggugacggggaaucaggguucgauuccggagagggagcc
ugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuaccc
acucccgacccggggagguagugacgaaaaauaacaauacaggacucuuu
cgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauc
cauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaau
agcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuuggg
agcgggcggccgcccguccccgccucucggcgccccggggcccgaagcgu
uuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggaua
ccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuu
cggaacugaggccaugauuaagagggacggccgggggcauucguauugcg
ccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaag
cauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucga
agacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcg
augcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaa
agucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaagga
auugacggaagggcaccaccaggaguggagccugcggcuuaauuugacuc
aacacgggaaaccucacccggcccggacacggacaggauugacagauuga
uagcucuuucucgauuccgugggugguggugcauggccguucuuaguugg
uggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugc
uaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagag
ggacaaguggcguucagccacccgagauugagcaauaacaggucugugau
gcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgu
gugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgu
gauggggaucggggauugcaauuauuccccaugaacgaggaauucccagu
aagugcgggucauaagcuugcguugauuaagucccugcccuuuguacaca
ccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucgg
ccccgccggggucggcccacggcccuggcggagcgcugagaagacggucg
aacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggug
aaccugcggaaggaucauua
...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[[[.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>>[[..(((((.....<<<<<<<<<<<<<..>>>>.......<....
..>..)))))......]]...<<<<.<<<<......>>>>>>>>.]].]]
]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>
>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<.
.........>>>.>>.<.<<....>>.>...]]]]]].........<<<.
...<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<...
.>>>..>>>>>>.>>>......<<..<...........>..>>.......
..<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>.
.)))))).]]]............{{.......{{...[[[.[[....<<<
.<<<<<<<..>>>>>>>.>>><<...<<<..<<<<..>>>>.>>>.>>..
<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>
......>.>>>..>>>........{.[[.(((((((.....>>>>>>>>>
.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<<
<<<...<<<......>>>......>>>>>>>>..>>.......<<....>
>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<..
.<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<.
.<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..}}>>..
.>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]
..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<....
....>>..........<<<<<......<<<<<<.......<<.<<<....
....>>>.>>.....>>>>>>...<<.<<<..<<<<<<<<<....<<<.<
<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<
<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..
>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>
>>>>>.......>>>>>......>>>>.>>>.....<<.<<<........
<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>..
....<.....<<<<<..........>>>>>.....>.....>>>>>....
.<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>..
..<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<
<<<<<<<<<<<<<<.....>>>>>>>>>>>>.>.>>>>>...>>.>>>>.
.>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<..
..>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8btk Molecular basis of the TRAP complex function in ER protein biogenesis.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		K2 N4 S6 P8 Q13 L15 R31 A33 S53 N56 K58 Q59 G60 F61 P62 Q65 G66 R72 R74 L75 L76 C83 R85 R87 R88 T89 G90 R92 K93 R94 K95 V108 N110 V112 R131 R132 L133 G134 K136 R137 S139 R140 K149 R154 R159 K160 L162 K164 K168 R170 T171 K172 A173 P174 K175 I176 Q177 R178 V180 R183 Q186 H187 K188 R189 R190 K195 K196 R198 T199 K201 R231
Binding residue
(residue number reindexed from 1)		K2 N4 S6 P8 Q13 L15 R31 A33 S53 N56 K58 Q59 G60 F61 P62 Q65 G66 R72 R74 L75 L76 C83 R85 R87 R88 T89 G90 R92 K93 R94 K95 V108 N110 V112 R131 R132 L133 G134 K136 R137 S139 R140 K149 R154 R159 K160 L162 K164 K168 R170 T171 K172 A173 P174 K175 I176 Q177 R178 V180 R183 Q186 H187 K188 R189 R190 K195 K196 R198 T199 K201 R231
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019901 protein kinase binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0001890 placenta development
GO:0002181 cytoplasmic translation
GO:0002309 T cell proliferation involved in immune response
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006924 activation-induced cell death of T cells
GO:0007369 gastrulation
GO:0008284 positive regulation of cell population proliferation
GO:0022605 mammalian oogenesis stage
GO:0031929 TOR signaling
GO:0033077 T cell differentiation in thymus
GO:0042274 ribosomal small subunit biogenesis
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0048821 erythrocyte development
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030425 dendrite
GO:0032040 small-subunit processome
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0044297 cell body
GO:0048471 perinuclear region of cytoplasm
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8btk, PDBe:8btk, PDBj:8btk
PDBsum8btk
PubMed37170030
UniProtG1TM55|RS6_RABIT Small ribosomal subunit protein eS6 (Gene Name=RPS6)

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