Structure of PDB 6skg Chain Ae Binding Site BS01

Receptor Information

>6skg Chain Ae (length=174) Species: 311400 (Thermococcus kodakarensis)

GDPKRQRKKYETPSHPWIKERLDRERVLKRNYALKNKKELWRHETQLKEF
RRRARRLLAARGKQAEIERQQLLQRLYRLGLLPADAVLDDVLSLTVEDVL
ERRLQTIVYRKGLARTMKQARQLIVHGHIEVNGQVIRSPGYLVLREEEDT
ITYAKGSPFAKEGHPERMVIEQAK

Ligand information

>6skg Chain Aa (length=1463)

auuccgguugauccugccggaggccacugcuauggggguccgacuaagcc
augcgagucauggggcgcgcgcgcgcaccggcggacggcucaguaacacg
ucgguaaccuacccucgggagggggauaaccccgggaaacuggggcuaau
cccccauaggccugagguacuggaagguccucaggccgaaaggggcaugc
ccgcccgaggaugggccggcggccgauuagguaguuggugggguaacggc
ccaccaagccgaagaucgguacgggccaugagagugggagcccggagaug
gacacugagacacggguccaggcccuacggggcgcagcaggcgcgaaacc
uccgcaaugcgggcaaccgcgacggggggacccccagugccguggcagcc
acggcuuuuccggaguguaaaaagcuccgggaauaagggcugggcaaggc
cgguggcagccgccgcgguaauaccggcggcccgagugguggccgcuauu
auugggccuaaagcguccguagccgggcccguaagucccuggcgaaaucc
cacggcucaaccguggggcuugcuggggauacugcgggccuugggaccgg
gagaggccggggguaccccugggguaggggugaaauccuauaaucccagg
gggaccgccaguggcgaaggcgcccggcuggaacggguccgacggugagg
gacgaaggccaggggagcgaaccggauuagauacccggguaguccuggcu
guaaaggaugcgggcuaggugucgggcgagcuucgagcucgcccggugcc
ggagggaagccguuaagcccgccgccuggggaguacggccgcaaggcuga
aacuuaaaggaauuggcgggggagcacuacaagggguggagcgugcgguu
uaauuggauucaacgccgggaaccucaccgggggcgacggcaaggccagg
cugaaggucuugccggcgagaggaggugcauggccgccgucagcucguac
ugugaggcguccacuuaagugugguaacgagcgagacccgcgcccccagu
ugccaguccuccccgcuggggaggaggcacucuggggggaccgccggcga
uaagccggaggaaggagcgggcgacgguaggucaguaugccccgaaaccc
ccgggcuacacgcgcgcuacaaugggcgggacaaugggauccgaccccga
aaggggaagggaauccccuaaacccgcccucaguucggaucgcgggcugc
aacucgcccgcgugaagcuggaaucccuaguacccgcgugucaucaucgc
gcggcgaauacgucccugcuccuugcacacaccgcccgucacuccacccg
agcgggguccgggugaggccuggucucccuucggggaggccgggucgagc
cugggcuccgugaggggggagaagucguaacaagguagccguaggggaac
cuacggcucgauc

...<<<<<.[.((((>>>>>.<<<<<<<<<..<<<<<<.<<......<<<
.<<<..<<<..<<.<<<<<..>>>>>.>>>>>......<<........<<
<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....
>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<..>>
>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>
>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<
<<<............>>>>>.<<<<....>>>>...>>>>>>......<<
.<<<....<<<<....>>>>..>>>>>>>.>>>>>>..<<<<<<<<.>>>
>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<
<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>......
....<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<<<
<<<<<.....>>>>>>>>...>>>>>>>>..>>>>>>>>>...<<<<<<.
....<<<<<<<.<..<<<<<<<<<..<<<......>>>.....>>>>>>>
>>..>........<<....>>.>>>>>>>....>>>.>>>...>>>...>
>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>
.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>
...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>..
..>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<.
.....<<........>>..........<<<<<<<...<<....<<<.<<<
<.....>>>>.>>>..>>...<<.<<<..<<<<<<<<.....<<<<<<.<
<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<.
.<<<..<<<<<<<<...>>>>>>>>>>>...>>>>>>>.....<<<<<..
...>>>>>........>>>>>.....>>.>>>...>>>>>>>>....>>>
>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<..
..>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<...
.....>>>>>>>....>.....>>>>>>.....<<<<<<<.......>>>
>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<.
.<<<.<<<<<<<<<..<<<<<<<<<<<<<<..>>>>>>>>>>>>>>..>>
>>>>>>.>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>
>>>>>>>>.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6skg Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping.
• Resolution: 2.65 Å
• Binding residue (original residue number in PDB): G2 D3 P4 K5 Q7 R8 K9 S15 H16 W18 K36 N37 K38 R43 R54 Q65 Q72 R79 R116 T117 K119 R122 Q123 H127 Q135 S139 P140
• Binding residue (residue number reindexed from 1): G1 D2 P3 K4 Q6 R7 K8 S14 H15 W17 K35 N36 K37 R42 R53 Q64 Q71 R78 R115 T116 K118 R121 Q122 H126 Q134 S138 P139

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0043226 organelle
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6skg, PDBe:6skg, PDBj:6skg
• PDBsum: 6skg
• PubMed: 32555463
• UniProt: Q5JJF2|RS4_THEKO Small ribosomal subunit protein uS4 (Gene Name=rps4)