Structure of PDB 8off Chain Ab Binding Site BS01

Receptor Information
>8off Chain Ab (length=107) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTA
EILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPN
IQAVLLP
Ligand information
>8off Chain J (length=144) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gagaatcccggtgccgaggccgctcaattggtcgtagacagctctagcac
cgcttaaacgcacgtacgcgctgtccgccgcgttttaaccgccaagggga
ttactccctagtctccaggcacgtgtcagatatatacatcctgt
Receptor-Ligand Complex Structure
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PDB8off BRCA1-BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R43 V44 A46 T77
Binding residue
(residue number reindexed from 1)		R32 V33 A35 T66
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0008150 biological_process
GO:0031507 heterochromatin formation
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8off, PDBe:8off, PDBj:8off
PDBsum8off
PubMed37823591
UniProtP0C0S8|H2A1_HUMAN Histone H2A type 1 (Gene Name=H2AC11)

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