Structure of PDB 8oit Chain Aa Binding Site BS01

Receptor Information
>8oit Chain Aa (length=381) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTKMLWKHKALQKYMENLSKEYQTLEQCLQHIPVNEENRRSLNRRHAELA
PLAAIYQEIQETEQAIEELESMCKSLNKQDEKQLQELALEERQTIDQKIN
MLYNELFQSLVPKEKYDKNDVILEVTAGRTTGGDICQQFTREIFDMYQNY
SCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIP
EVGLSSRMQRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGAAAQH
VNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKD
KRQQQSARKLQVGTRAQSERIRTYNFTQDRVSDHRIAYEVRDIKEFLCGG
KGLDQLIQRLLQSADEEAIAELLDEHLKSAK
Ligand information
>8oit Chain B8 (length=1558) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggg
aagauuuauagguagaggcgacaaaccuaccgagccuggugauagcuggu
uguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccuc
uaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuug
gacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauag
uaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccca
cuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauugga
ccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaa
acauucuccuccgcauaagccugcgucagauuaaaacgaacugacaauua
acagcccaauaucuacaaucaaccaacaagucauuauuacccucacuguc
aacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaa
cucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcauc
accaguauuagaggcaccgccugcccagugacacauguuuaacggccgcg
guacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauaggga
ccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccag
ugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaa
gacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaaaccca
cagguccuaaacuaccaaaccugcauuaaaaauuucgguuggggcgaccu
cggagcagaacccaaccuccgagcaguacaugcuaagacuucaccaguca
aagcgaacuacuauacucaauugauccaauaacuugaccaacggaacaag
uuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaau
aggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgc
uauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguuc
agaccggaguaauccaggucgguuucuaucuacuuucaaauuccucccug
uacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccg
uaaaugauaucaucucaacuuaguauuauacccacacccacccaagaaca
ggguuugu
<<<.......<<<<....................................
.<......>...............<<.....>>.............>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....
<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>
....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>.
.<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......
....>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>
>>>...<<<......>>>....<<<.<<<...<..............<..
..<<<.........>>>....>.......<<<......>>>.........
...........................>...>>>>>>........>>>>>
>...<<<<<......>>>>>.........>>>>>><......<<..<<<.
...>>><<<<..<<<<........<<<<<..<.....>..>>>>>.....
.<<<...<<<<.......................>>>>.......>>>..
...<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<...
......<......<<<<<<..<<<.........>>>...<<<<<<.....
........>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<
<<......>>>>>>........<...........<<<<<<.....>>>>>
>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>
>.....>.....<<<<<........>>>>>.......<<..<<<.<<...
...<<<<.<<<<<<..<<<<<.<<<<<<<<....<<<........<<<..
..>>>.......>>>......>>>>>>>>>>>>>..<<<<.....>>>><
<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>.
.>>>...........>>.........<<<....>>>............>>
>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>
>>>...>.>>.>.......<.<<<.<<<<<<..<<.<<<<<<......>>
>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>...
.<<<<<<<....>>>.>>>>....>>..>>>.>>.....<<<.<<<....
.............>>>.>>><<<<<...<<<....>>>.>>>>>......
<<<................>>>.................<<<<.......
>>>>....
Receptor-Ligand Complex Structure
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PDB8oit Molecular basis of translation termination at noncanonical stop codons in human mitochondria.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R104 K298 F305 R306 K308 G309 A310 A311 A312 Q313 H314 N316 K317 T318 D319 R339 Q341 I342 R355
Binding residue
(residue number reindexed from 1)		R40 K234 F241 R242 K244 G245 A246 A247 A248 Q249 H250 N252 K253 T254 D255 R275 Q277 I278 R291
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003747 translation release factor activity
GO:0016149 translation release factor activity, codon specific
Biological Process
GO:0006412 translation
GO:0006415 translational termination
GO:0070126 mitochondrial translational termination
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8oit, PDBe:8oit, PDBj:8oit
PDBsum8oit
PubMed37141370
UniProtO75570|RF1M_HUMAN Peptide chain release factor 1, mitochondrial (Gene Name=MTRF1)

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