Structure of PDB 8oeq Chain AZ Binding Site BS01

Receptor Information
>8oeq Chain AZ (length=292) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MQKEFRTSAYHSRFQTPFRRRQEGKTDYYQRKRLVTQHKAKYNSPKYRLV
VRFTNKDIIAQIVSAHITGDVVFTAAYAHELPRYGIKYGLTNWSAAYAVG
LLVARRALQKLGLDETYTGVEEVEGEFELTEAVEDGPRPFKVFLDIGLQR
TTTGARVFGVLKGASDGGLYVPHSPNRFPGWDIEAEELDAELLRKYIFGG
HVAEYMEELLDDDEEKYKSIFKNYIEEEIESEDVEEIYANAHEAIRADPS
FKPTEKKFTKEQYKAESKKYRQQKLTRAERQAKVAKKIAEFK
Ligand information
>8oeq Chain AS (length=3199) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauugcggu
uuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaaugu
ggcacggcuucugcuguguguuauagccucugacgauacugccagccuag
accgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaaguc
gcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuug
gguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauu
agggugcaccaucgaccgauccugauguguucggauggauuugaguaaga
gcauagcuguugggacccgaaagauggugaacuaugccugaauaggguga
agccagaggaaacucugguggaggcucguagcgguucugacgugcaaauc
gaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuagua
gcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguu
uuaugagguaaagcgaaugauuagaagucuugggguugaaaugaccuuaa
cuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaac
guggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaa
cuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacg
cucaucagacaccacaaaagguguuaguucaucuagacagccggacggug
gccgcuaaggaguguguaaacucaccggccgaaugaacuagcccugaaaa
uggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuug
acgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcug
uaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaa
uauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaa
cagcaguuggacauggguuagucgauccuaagagauggggaagcuccguu
ucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaa
auuccggaacuuggauauggauucuucacggcaacguaacugaaugugga
gacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuua
ucacccuggaauugguuuauccggagauggggucuuauggcuggaagagc
gcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaaucca
caggaaggaauaguuuucaugccaagucguacucauaaccgcagcagguc
uccaagguuaacagccucuaguugauagaauaauguagauaagggaaguc
ggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucggg
cacguuuaacgaucaacuuagaacugguacggacaaggggaaucugacug
ucuaauuaaaacauagcauugugauggucagaaagugauguugacacaau
gugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaag
cgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugc
cucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacu
gucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggca
gaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauu
gugaaaagacauggaggguguagaauaagugggagcuucggcgccgguga
aauaccacuaccucuauaguuuuuuuacuuauucaaugaagcggagcugg
aggucaaacuccacguucuagcauuaagcccucugggcgauccggguuga
agacauugucagguggggaguuuggcuggggcggcacaucuguuaaacga
uaacgcagguguccuaagggggacucauggagaacagaaaucuccaguag
aacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaa
ccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcua
gaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagc
guucauagcgacauugcuuuuugauucuucgaugucggcucuuccuauca
uaccgaagcagaauucgguaagcguuggauuguucacccacuaauaggga
acgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacug
augaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguuca
uucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcu
accaucugcuggauuauggcugaacgccucuaagucagaauccaugcuag
aacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuu
uuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaagg
cuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaau
ccuuugcauacgacuuagauguacaacggaguauuguaagcaguagagua
gccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu
.......................<<<<<<.....<......>......>>
>>>.>.........<<....>>..<<<<<......<<.....>>.....>
>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.........
....<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>
>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....<<<<
<..((((((>>>>>..>>>...............................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<.........
...>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<.....
.<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>
>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>
..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<
<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<...
.>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....
>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<...
.<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>
>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>.
.>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<
<<<<<.....<<<....<<<....<<<<...<<<<<.......>>>>>.>
>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>
>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>
.>>>>....<<<..[...>>>...<<<<<<<..<<<<(((.....<<<<<
<.....<<.....]....<<<.<<<<<<<<<<.......<<<<<.<<<..
.>>>.........<<....>>...>>>>>...>>>>>>>>>>>>>.....
.....))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.......
..>>..>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<.
...>>>.>>>>...>>>>>>>>>>........>>>>>><<.....<<...
..<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...
<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>...
.......<<<<<<....>>>>>>......>>....>>...<<<<<.....
...>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<
...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<..
..<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<
<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>
>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>
>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<......
...<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..
.........>>>>>..>>>>>>.>>............<<<<<<<<<..<<
<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>
>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>
>>.>>>>..>>>>><<<<<<.......>>>>>>........<........
...<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>
..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>..
..<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..
<<<<<<<<<<<<...<<.................<......>........
............>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<<
<<......>>>>>..............<<<<...>>>>..>>>>..>>>>
>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<.......
....>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>....
.<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>
.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>
>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<
.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.
<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>
..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>
>>....<<<<<<<<..<<<<.<.<<<<<.................>>>>>
.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>
>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>.
...>>>>>>>>.....<<<<<<.<<<.<.....<<..........<<<<.
...>>>>......>>.......<<<<<<...<<<<<<<..<<<......>
>>..>>>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<
<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<
<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
Resolution3.3 Å
Binding residue
(original residue number in PDB)
M3 Q4 K5 R8 Y12 R15 F16 Q17 R23 G26 T28 Y31 R35 L36 K43 Y44 K48 Y49 L113 P139 R140 P141 F145 I148 T153 P174 H175 S176 N178 R179
Binding residue
(residue number reindexed from 1)
M1 Q2 K3 R6 Y10 R13 F14 Q15 R21 G24 T26 Y29 R33 L34 K41 Y42 K46 Y47 L111 P137 R138 P139 F143 I146 T151 P172 H173 S174 N176 R177
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