Structure of PDB 6uz7 Chain AZ Binding Site BS01

Receptor Information
>6uz7 Chain AZ (length=134) Species: 28985 (Kluyveromyces lactis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KFLKAGKVAVVVRGRYAGKKVVIVKPHDEGTKSHPFGHALVAGIERYPLK
VTKRQGAKKVAKRTKIKPFIKVINYNHLLPTRYTLDVEAFKSVVSTETFE
EPSQREEAKKVIKKAFEERHQAGKNQWFFTKLNF
Ligand information
>6uz7 Chain 5 (length=3269) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucaaaucagguaggaauacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagc
ggcaaaagcucaaauuugaaaucuggcgucuucgacguccgaguuguaau
uugaagaaggcaacuuuguagcugguccuugucuauguuccuuggaacag
gacgucauagagggugagaaucccguguggcgaggaucccaguuauuugu
aaagugcuuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcauuugaucagacaugggccagcauc
aguuuuagcgguuggauaaauccucgggaauguggcucugcuucgguaga
guguuauagcccgugggaauacagccagcugggacugaggauugcgacuu
uugucaaggaugcuggcguaaugguuaaaugccgcccgucuugaaacacg
gaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacg
cguaaugaaagugaacguaggugagggcccgcaagggugcaucaucgacc
gauccugaugucuucggauggauuugaguaagagcauagcuguugggacc
cgaaagauggugaacuaugccugaauagggugaagccagaggaaacucug
guggaggcucguagcgguucugacgugcaaaucgaucgucgaauuugggu
auaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaag
uuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaa
ugauuagagguaccgggguugaaaugaccuugaccuauucucaaacuuua
aauauguaagaaguccuuguugcuuaauugaacguggacauuugaaugaa
gagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggauga
accgaacguggaguuaaggugccggaauacacgcucaucagacaccacaa
aagguguuaguucaucuagacagccggacgguggccauggaagucggaau
ccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaa
auggauggcgcucaagcguguuaccuauacuccaccgucaggguuaauau
gaugcccugacgaguaggcaggcguggaggucagugacgaagccuaggcu
guaaagcuggguagaacggccucuagugcagaucuuggugguaguagcaa
auauucaaaugagaacuuugaagacugaaguggggaaagguuccacguca
acagcaguuggacguggguuagucgauccuaagagauggggaagcuccgu
uucaaaggccuaauuuucuaggccaccaucgaaagggaauccgguuaaua
uuccggaaccuggauauggauucuucacgguaacguaacugaauguggag
acgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuau
caccccggaauugguuuauccggagagggggucuuauggcuggaagagcc
cagcccuugugcuggguccggugcgcccgcgacggcccuugaaaauccac
aggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucu
ccaaggugaacagccucuaguugauagaauaauguagauaagggaagucg
gcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucggaa
gugagggccuuggucagacgcggcguuguagacggccuugguaggucucu
uguagaucugcaauuaacgaucaacuuagaacugguacggacaaggggaa
ucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguu
gacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauu
caaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguag
ccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgaga
uucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgg
gcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuagu
uugacauugugaagagacauagaggguguagcauaagugggagcuucggc
gccagugaaauaccacuaccuuuauaguuucuuuacuuauucaauuaagc
ggagcuggaauucauuuuccacguucuagcauucaaaguccuauacgggc
ugauccggguugaagacauugucagguggggaguuuggcuggggcggcac
aucuguuaaacgauaacgcagauguccuaagggggacucauggagaacag
aaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuuca
gugugaauacaaaccaugaaaguguggccuaucgauccuuuagguccucg
gaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuu
guggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucg
gcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucac
ccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuag
uuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacga
gaggaacaguucauucggauaauugguuuuugcggcugucugaucaggca
uugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaaguca
gaauccaugcuagaacgcgaugauuucuuugccuugcacaauauagaagg
auaagaauaaggcgucuuuuuggcgucgcugaaccauagcaggcuggcaa
cggugcucuuagcggaaaggcuuugggugcuugccggcgaauugcaaugu
cauuuugcgcaaggauaaaucauuuguauacgacuuaaauguacaacagg
guauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaag
ccuucguugucugauuugu
........................<<<<<<.....<......>......>
>>>>.>.........<<....>>..<<<<<......<<.....>>.....
>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>
>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>
>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....
>>>>>>>>>>>........<<<<<<<........>>>>>>>.....((((
(..<<<<<<)))))..]]]...............................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<........<<<<<<<.<
<<<<<<<<<<<<<<.....<<<<.<<<<......<<<<<<<....>>>>>
>>.......>>>>.>>.>.>.>>>>>.>>>>>>>>>>........<<<..
..>>>.....>>>>>>>.....>>>>>>>>>>>..<<<<........>>>
><<<<<<.....<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>
>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<
<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>...<<
.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>
>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>
>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....
<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....
<<<....<<<<..<<<<<<<.....>>>>>>>>>>>....>>>..>.>>.
....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..
>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<.....
.>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<.........
.<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>...
.>>.........<<......>>...>>>>>...>>>>>>>>>>>>>....
......))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<......
...>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<
....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<..
...<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<..
.<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..
......<<<<<<......>>>>>>....>>....>>...<<<<<......
..>>>>>))<<<<.<<<<<<<...<.<<<....>>>.......<<<<<<.
..<<<<.<<<<.<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<...
.<<<<<.....<<<.....>>>.....>>>>>.....>>>>>.....<<<
<<<<......>>>>>>>>>>>...>>.>>>>.>>>>.........>>>>>
>.....>....>>>..>>>>>>>>>>>>..>>.....<<......>>>>>
>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.......
..<.....<<<<<...............>>>>><<.<<<<<<<<<<<...
..<...<<<..<<<<....<<<<..>>>>....>>>>..>>>........
.......>.........>>>>>..>>>>>>.>>............<<<<<
<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>...
...>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>
>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<
...........<<<<<.......>>>>>.....>.....>>....>>.>>
>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<.......
.>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<
<<<<<<..<<<<<..<.....<<<<..........<<<<<..<<....>>
............>>>>>.>>>>.....>...>>>>>...<<<<<.....<
<<<................................<..<.<.....>>..
>..>>>>..>>>>>.....>>>>>>>>..>>>>>....<<.....>>...
<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<....
...>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<...
....>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.
>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.
<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<
<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........
>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>..
..}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<........
.......>>>>>>.><<<<<...<<<<....<<<<<<<<<.}}}..>>>>
..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>
...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<
..........<<<<<<.....>>>>>>......>>.......<<<<<<..
.<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>............
.>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<
<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....
>>>>.>>>>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6uz7 Long-range interdomain communications in eIF5B regulate GTP hydrolysis and translation initiation.
Resolution3.6 Å
Binding residue
(original residue number in PDB)
G16 R17 F38 R48 T54 K55 R56 G58 K60 K67 K69 K73 V74 N76 H79 R107 K112 K115
Binding residue
(residue number reindexed from 1)
G14 R15 F36 R46 T52 K53 R54 G56 K58 K65 K67 K71 V72 N74 H77 R105 K110 K113
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6uz7, PDBe:6uz7, PDBj:6uz7
PDBsum6uz7
PubMed31900355
UniProtQ6CPN9

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