Structure of PDB 6c5l Chain AY Binding Site BS01

Receptor Information
>6c5l Chain AY (length=351) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LAQRLEGLRGYLDIPQKETRLKELERRLEDPSLWNDPEAARKVSQEAARL
RRTVDTFRSLESDLQGLLELMEELPAEEREALKPELEEAAKKLDELYHQT
LLNFPHAEKNAILTIQPGAGGTEACDWAEMLLRMYTRFAERQGFQVEVVD
LTPGPEAGIDYAQILVKGENAYGLLSPEAGVHRLVRPSPFDASGRRHTSF
AGVEVIPEVDEEVEVVLKPEELRIDVMRASGPGGQGVNTTDSAVRVVHLP
TGITVTCQTTRSQIKNKELALKILKARLYELERKKREEELKALRGEVRPI
EWGSQIRSYVLDKNYVKDHRTGLMRHDPENVLDGDLMDLIWAGLEWKAGR
R
Ligand information
>6c5l Chain AA (length=1504) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacg
ggugaguaacgcgugggugaccuacccggaagagggggacaacccgggga
aacucgggcuaaucccccauguggacccgccccuugggguguguccaaag
ggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggg
guaauggcccaccaaggcgacgacggguagccggucugagaggauggccg
gccacaggggcacugagacacgggccccacuccuacgggaggcagcaguu
aggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggag
gaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccga
cgaggggacugacgguaccgggguaauagcgccggccaacuccgugccag
cagccgcgguaauacggagggcgcgagcguuacccggauucacugggcgu
aaagggcguguaggcggccuggggcgucccaugugaaagaccacggcuca
accgugggggagcgugggauacgcucaggcuagacggugggagagggugg
uggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccg
auggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcg
uggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaug
cgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgc
gccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggg
ggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaaga
accuuaccaggccuugacaugcuagggaacccgggugaaagccuggggug
ccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucg
ugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguu
aguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcg
ggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggc
gacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggg
gagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccg
accccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggu
gaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgg
gcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggc
ccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggc
ugga
....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<
.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>.....
.<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<...
...>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<
<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<
.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>
>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>
>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<
......<<<<....>>>>.....>>>>....<<<<<........<<<<..
...>>>>..........>>>>>......<<<<<((....<<<<<.....<
...)).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((
.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<....
.>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<
<....<<<<<<<.<..<<<......>>>.....>.>>>>>>.>.......
...<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<
<<<...<<...<<<<.........>>>>...>>>>>>>>..........<
<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>
>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<
<<<.<<.<<.<<<<<<..<<<<<<<<<<......<<........>>....
......<<<<<<<.......<<<<<<...<<<<<<<....>>>>>>>...
.<<.....>>.....>>>>>>..<<<.<<<..<<<<<.<......<<<<<
<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<
<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>
>>........>>>>.......>..>>...>>>>>>>>>...>>>>>>>..
.>>.>>>>>>>>.....<<<<<<<......<<..<<..<<<<....>>>>
..>>....>>......>>>>>>>...........<<<<<<<........>
>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>
......>>...>>.>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<
<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>
>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>
>...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6c5l Conformation of methylated GGQ in the Peptidyl Transferase Center during Translation Termination.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		E78 L79 P80 G123 A124 G126 R188 S198 R200 R201 W307 G308 Q310 K318 Y320 K322 M329
Binding residue
(residue number reindexed from 1)		E73 L74 P75 G118 A119 G121 R183 S193 R195 R196 W302 G303 Q305 K313 Y315 K317 M324
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003747 translation release factor activity
GO:0016149 translation release factor activity, codon specific
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
GO:0006415 translational termination
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6c5l, PDBe:6c5l, PDBj:6c5l
PDBsum6c5l
PubMed29403017
UniProtQ5SM01|RF2_THET8 Peptide chain release factor RF2 (Gene Name=prfB)

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