Structure of PDB 8ppl Chain AX Binding Site BS01 |
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| >8ppl Chain A2 (length=1780)
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uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuugguga
cucuagauaaccucgggccgaucgcacgccccccguggcggcgacgaccc
auucgaacgucugcccuaucaacuuucgaugguagucgccgugccuacca
uggugaccacgggugacggggaaucaggguucgauuccggagagggagcc
ugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuaccc
acucccgacccggggagguagugacgaaaaauaacaauacaggacucuuu
cgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauc
cauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaau
agcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuuggg
agcgggcgggcgguaccgcccguccccgcccgccucucggcgccccgggg
cccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagc
cgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuu
uguugguuuucggaacugaggccaugauuaagagggacggccgggggcau
ucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggacc
agagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaaguc
ggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaug
ccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuucc
gggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaa
acuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuu
aauuugacucaacacgggaaaccucacccggcccggacacggacaggauu
gacagauugauagcucuuucucgauuccgugggugguggugcauggccgu
ucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagac
ucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaa
cuucuuagagggacaaguggcguucagccacccgagauugagcaauaaca
ggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacu
ggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaa
ccccauucgugauggggaucggggauugcaauuauuccccaugaacgagg
aauucccaguaagugcgggucauaagcuugcguugauuaagucccugccc
uuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcc
cucggaucggccccgccggggucggcccacggcccuggcggagcgcugag
aagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguu
uccguaggugaaccugcggaaggaucauua |
...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[{..........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>>[[..(((((.....<<<<<<<<<<<<<..>>>>.......<....
..>..)))))......]]...<<<<.<<<<......>>>>>>>>..}.]]
]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>
>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<.
.........>>>.>>.<.<<....>>.>...]]]]]].........<<<.
...<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<...
.>>>..>>>>>>.>>>......<<..<...........>..>>.......
..<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>.
.)))))).]]]............{{.......{{...[[[.[[....<<<
.<.<<<<<<<<<<..>>>>>>>>>>.>.>>><<...<<<..<<<<<>>>>
>.>>>.>>..<<<<<<.<.......<<...<.......>.<<<<......
.>>>>...>>......>.>>>..>>>........{.[[.(((((((....
.>>>>>>>>>.))))))).]].}....]]....<<<<<<..<...<<<<.
.<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>....
...<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<
<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<
<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...
<<..}}>>...>>.....>>>.....<<<......<<<......>>>...
.>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<..
....<<........>>..........<<<<<......<<<<<<.......
<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<
<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<
<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>
>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.
>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<
<<........<.......<<<.<<<<....>>>>.>>>....>.......
..>>>.>>............<<<<<..........>>>>>..........
.>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>
>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<
.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>.
..>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<
<<<<<<<<....>>>>>>>>>......... |
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| PDB | 8ppl Universal features of Nsp1-mediated translational shutdown by coronaviruses. |
| Resolution | 2.65 Å |
Binding residue
(original residue number in PDB) | G2 K3 C4 R5 G6 R8 T9 R11 K12 H16 R17 R18 Q20 K21 W22 H23 D24 K28 T34 L36 K37 A38 A44 S45 H46 A47 K48 K60 N63 S64 A65 I66 R67 K68 R71 K76 N87 D88 G104 G106 R107 K108 H110 V112 G113 D114 R119 K124 S129 K137 K138 |
Binding residue
(residue number reindexed from 1) | G1 K2 C3 R4 G5 R7 T8 R10 K11 H15 R16 R17 Q19 K20 W21 H22 D23 K27 T33 L35 K36 A37 A43 S44 H45 A46 K47 K59 N62 S63 A64 I65 R66 K67 R70 K75 N86 D87 G103 G105 R106 K107 H109 V111 G112 D113 R118 K123 S128 K136 K137 |
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