Structure of PDB 4v4n Chain AX Binding Site BS01

Receptor Information

>4v4n Chain AX (length=432) Species: 2190 (Methanocaldococcus jannaschii)

KKLIPILEKIPEVELPVKEITFKEKLKWTGIVLVLYFIMGCIDVYTAGAQ
IPAIFEFWQTITASRIGTLITLGIGPIVTAGIIMQLLVGSGIIQMDLSIP
ENRALFQGCQKLLSIIMCFVEAVLFVGAGAFGILTPLLAFLVIIQIAFGS
IILIYLDEIVSKYGIGSGIGLFIAAGVSQTIFVGALGPEGYLWKFLNSLI
QGVPNIEYIAPIIGTIIVFLMVVYAECMRVEIPLAHGRIKGAVGKYPIKF
VYVSNIPVILAAALFANIQLWGLALYRMGIPILGHYEGGRAVDGIAYYLS
TPYGLSSVISDPIHAIVYMIAMIITCVMFGIFWVETTGLDPKSMAKRIGS
LGMAIKGFRKSEKAIEHRLKRYIPPLTVMSSAFVGFLATIANFIGALGGG
TGVLLTVSIVYRMYEQLLREKVSELHPAIAKL

Ligand information

>4v4n Chain A1 (length=2969)

ggacgcuaagccgcccgguggauggcucggcucggggcgccgacgaaggg
cguggcaagcugcgauaagccccggcgaggcgcaggcagccgucgaaccg
gggauucccgaaugggaccucccgcggcuuaugccgcacuccgaggggga
acgcggggaauugaaacaucuuaguacccgcaggaaaagaaagcaaaagc
gaugccgugaguaggggcgaccgaaaacggcagagggcaaacugaacccc
gggccgacgagguucgggggaugugggguuguagggcccccguaugagac
ccucgcgggugaagccgaaguccgcuggaacgcggcgccggagaggguga
uagccccguaggcguaagcccgcagggucucgggggacccugaguaccgu
cgguuggauauccggcgggaagcugggaggcaucggcucccaacccuaaa
uacgucccgagaccgauagcgaacuaguaccgugagggaaagcugaaaag
caccccgggaggggggugaaaagagccugaaaccgggcggcgauaggagg
gugcggcccgaaaggaaugagccuccccgaaggaaaccgcggcgacgcgg
gaguacgaggggaggggaccgggguugcaccguccgucuugaaacacggg
gcagggaguucgcggccguggcgagguuaaggggguuaagccccguagcc
gcagggaaaccgacaugcccgcagccgggccggugaggggcggggugcga
aagcgcccggagucacggccgcgagacccgaaaccggucgaucuagcccg
gggcagggugaagucccucaaccgagggauggaggcccgcuaggggugcu
gaugugcaguucgcucccgugaccccgggcuaggggugaaaggccaaucg
aggccggagauagcugguucccgccgaaucaucccgcaggauggccuccc
cggagguaggcggugggguagagcacugauuggaggugcagggggcgaaa
gcccccggccuccugucaaacuccgaacccaccgccgccguagauggggg
gaguaggguggcgguguaagccguccaccgagaggggaacaacccagacc
gggguuaaggccccaaagugccggcuaaguguuacuccaaaggguguccc
gggccuuagacagcggggagguaggcuuagaagcagccauccuuuaaaga
gugcguaacagcucacccgucgagguccggggccccgaaaauggacgggg
cucaagccggccgccgagaccccggcgcacggagugaucggguaggcggg
cgugccgguggcguagaagccgggccguaagguccgguggagccgccggu
aucgcggauccugccgggaguagcagcguagucgggugagaaucccgacc
gccggaggggccaggguuccacggcaauggucgucagccguggguuaguc
gguccuaaccccgcccguaacucggcgcgggggaaagggaaacggguuua
uauucccguaccgcggggguaggugcggcaacgcaagcccggagggugac
gccucgggguaggcggaccggccgaugaggccggcuaagcguauaagccc
ggggagugccguaauggcgagaaccgggugaaagcgcgaauggccccccc
guuagggggguuccgccgaucccuggggcccgugaaaagcccuccgggaa
uuccgaucccccgcgaccguaccgagaaccgacacaggugccccugggug
agaagccuaaggcgugucgggggaaacccggccgagggaacucggcaaac
uggccccguaacuucgggagaaggggugccugcgggugcguaacccgcag
gucgcagugacuaggggggcccgacuguuuaauaaaaacacaggucccag
cuagcccgaaaggguuuguacuggggccgacgccugcccagugccgguau
gugaagcccggguacaaccgggugaagcaccgguaaacggcggggguaac
uauaacccucuuaagguagcgaaauuccuugucgguuaaaugccgaccug
caugaauggcguaacgagguccccgcuguccccggccggggcccggcgaa
accucugccuggcgcgcaugccagggacccccggugggaagcgaagaccc
cauggagcuuuacugcagccugccguugccacacggcggggggugcgcag
cguaggcgggaggcgucgaagcccggccuccgggucggguggagccgucc
augagacaccgcccacuccccgcuguguggcuaacccccgaaagggggga
cagcgguaggugggcaguuuggcuggggcggcacgccuccgaaaagguau
cggaggcgcccuaaggucggcucaggcgggucaggaauccgccguagagu
gcaagggcaaaagccggccugacuggacccguaacagaggcggguccagc
cccgaaaggguggccuagcgaaccccugugccuccccggugggggccagg
gaugacagaaaagcuacccuggggauaacagagucgucucgggcgagagc
ccauaucgaccccgaggcuugcuaccucgcugucggcucuucccauccug
gcccugcagcaggggccaaggguggggguguucacccauuaaaggggaac
gugagcuggguuuagaccgucgugagacaggucggaugcuaucuaccggg
gguguuggccgccugaggggaaggugccccuaguacgagaggaacagggu
gccgcggccucuggucuaccgguuguccucccgggcaucgccgggcagcu
acgccgcagccgauaaggccugaaagcaucuaaggccgaagcggcccccg
aaaauaggcggccguggacgagggcucggguagaagacccgguugauagg
gcggggauguaagcgggaagggucaaccgacccgcuuaguccgccgcccc
uaaucgcccgagguccugc

<<.......<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<
<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>
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.<<<<<<.....<......>......>>>>>.>.........<<....>>
..<<<<<<.....<<.....>>....>>>>>>..<<<....<<...<<<<
<<<<<.....>>>>>>>>>.....>>..........<<<.<.......<<
<<<.<<<<<<...<<<.....<<<<......>>>>.((......<<<...
..))>>>...>>>....>>>>>>>>>>>...>>>>...........<<<<
<<<........>>>>>>>......<<<<<.((((((>>>>>..>>>....
..>>>>>>>>>.>>...............<<....>>....>>.......
..<<<<.....>>>>................>>>>>>>>>>........<
<<<<<<<<<....<<......<<<<<<<........<<<<<....>>>>>
........>>>>>>>...>>.>>>>>>>>>>..<<<<........>>>><
<<<<<....<<<<<<<<<<<<<..<<<....<<<<.....>>>>...>>>
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..>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<
<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<<.<<.
<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>.....
.>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<
<<..<<<.<<<<<<<<<...<<<....<<.....<..<<..<<<<.....
..>>>>.>>.>....>>...>>.>...>>>>>>>>>>>>.....>>>>>>
>.>>.<<..<<<<<<....>>>>>>..>>....<<<......>>>...<<
<<<<<...<<<(((.....<<<<<<.....<<.........<<<.<<<<<
<<<<........<<<<<.<<...<<<<.......>>>>...>>.......
..<<......>>...>>>>>....>>>>>>>>>>>>..........)))>
>....>>>>>>.>>>...>>>>>>><<<<<...>>>..>>....>>>>>>
<.<<<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>>
>..>.....>>>>>><<.....<<......<<<<<<.......>>>>>><
<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<
<<<<<...<<<<<<<<<.....>>>.>>>>>>....>>>..<<<<<....
....>>>>>))<<<<<<<<.....<<<....>>>......<<<<<<<...
<<<<<<<<<...<..<.<<<<<<.....>>>>>><...<<<<....<<<<
<<.....<<<<...>>>>.....>>>>>>....>>>>....><.<<<<<<
....>>>>>>.>.>..>...>>>>>>>>>.........>>>>>>>.....
.......>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<<.
....>>>>..>>>>...<<<<.....<<<<<<<<.<<.............
..<<<<<...............>>>>><<<<<<<<<<.....>>>>>>>>
>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.
...<<<<....>>>>......>>>>>>>.<<<<<.<<<..<<<<<<<..<
<<...<<<<<<......>>>>>>...>>>>>>>>..>>>>><<<<<<...
....>>>>>>........<...........<<<<<<.....>>>>>>...
..>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...
.>>....<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<
<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<<......
....<<<<<...<.......<<<<<<<<....>>>>>>>>....>.....
........>>>>>.>>>>>>>>>>>>>>>>>...<<<<<....>>>>>..
..>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<..........
.>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<
...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.
<<<....>>>.>>))).......<<<<<.<<<<<.))))))>>>>>>>>>
>..........>>>>..>>>>>>.......<<<<.<.<<<<<<...<<..
.....>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<
<<<<<......>>>>>>>..>>..<<<.......>>>......>>>>>..
>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>
>>....<<<<<<<<..<<<<..<<<<<<<.................>>>>
>>><<<<<....<<<...<<<<<<<<<<....>>>>>..>>>>>...>>>
..>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>>
......>>>>>>>........<<<<<<<<<.......>>>>>....<<<<
<<<<<<<<....<<<<<..<<.....>>..>>>>>...>>>>.>>>>>.>
>>...>>>>.....>>...

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4v4n Structure of the SecY channel during initiation of protein translocation.
• Resolution: 9.0 Å
• Binding residue (original residue number in PDB): R239 I240 K241 F359 K361 P428 A429
• Binding residue (residue number reindexed from 1): R238 I239 K240 F358 K360 P427 A428

Gene Ontology

Molecular Function

• GO:0005048 signal sequence binding
• GO:0008320 protein transmembrane transporter activity

Biological Process

• GO:0006605 protein targeting
• GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
• GO:0015031 protein transport
• GO:0065002 intracellular protein transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:4v4n, PDBe:4v4n, PDBj:4v4n
• PDBsum: 4v4n
• PubMed: 24153188
• UniProt: Q60175|SECY_METJA Protein translocase subunit SecY (Gene Name=secY)