Structure of PDB 8ove Chain AW Binding Site BS01

Receptor Information
>8ove Chain AW (length=85) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GFFDSDLSYPTVRTERMKHKRRRLVQGPNSYFMDVKCPGCKNITVVYSHA
TSEVKCNGCATLLCRPTGGKAMLVTGCGFRKKPDH
Ligand information
>8ove Chain AA (length=1836) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcgcaggaaucugcgcauggcucauuacau
cagacguaaucugccgccaaaauuuugcgcauuacuggauaacuuggcga
aacgccaagcuaauacaugaaccaaucggacgcucucuuugggacgucca
gcgaaugaaugaaaccaacgccuccggaggcaguaacacucagacguguu
gacucaauucauuccgugcgaaagccgagcugcucggcgucuacugacga
acaacugcccuaucagccagugauggccguguaguggacugccauggcgu
ugacgggagcgggggauuaggguucgauuccggagagggagccugagaaa
uagcuaccacuucuacggagggcagcaggcgcgcaaauugcccaaugucg
aaaaaauacgaugaggcagcgaaaagaaauagagccgaccgugugguugu
uuucaaugggggauacucaaacccauucaauaucgaguaacaauuggagg
acaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauau
uaaugcuguugcuguuaaaggguucguaguugaacugugggccacguagu
guggugccguaccagucccguaccucgacguguuuugacccacgcccucg
uggcccagauacagaaacacgggagcaguucgcaugucaugcaugggcgu
ccgugaauuuuacugugaccaaaaagaugcgaccaaagcaguuugccgac
uugaauuacaaagcaugggauaacgaagcaucagcccugggguuauguug
guuuuagaaguccuugggagauuauggggccgccgcgcggcuucgaauga
aggaggguaguucgggggagaacguacuggugcgucagaggugaaauucu
uagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuu
ccucaaucaagaaccaaaguguggggaucaaagaugauuagagaccauug
uaguccacacugcaaaccaugacacccaugaauuggggagugccucucag
cacguuucuuacuucuucacgcgaaagcuuggagguuacagucucagggg
ggaguacguucgcaagagugaaacuuaaagaaauugacggaauggcacca
caagacguggagcgugcgguuuaauuugacucaacacggggaacuuuacc
agauccggacagggugaggauugacagauggaguucuuucucgauccccu
gaaugguggugcauggccgcuuuuggucgguggagugauuuguuugguug
auuccgucaacggacgagauccaagcugcccaguaggugccgggauuguc
cacacaggacagcauccuucuuuaggccccuucucugcgggauuccuugc
uuuucgcgcaaggugagauuuugggcaacagcaggucugugaugcuccuc
aauguucugggcgacacgcgcacuacaaugucagugagaacaagagucga
cgcucccgcuugaucaaaagagcggggaaaccacggaaucacguagaccc
acuugggaccgaguauugcaauuauuggucgcgcaacgaggaaugucucg
uaggcgcagcucaucaaacugugccgauuacgucccugccauuuguacac
accgcccgucguuguuuccgaugauggugcaauacaggugaucggaccgu
caccgaaaguucaccgauauugcuucaauagaggaagcaaaagucguaac
aagguagcuguaggugaaccugcagcuggaucauuu
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<..>>>...>>.>>......<<........
<<<..<<..<<...<<..<................<<.....<<<<<<..
...>>>>>>......>>..........<<<<<.<<<.....>>>>>>>>.
<<<<<<<<<<....(((((<<<<....>>>>...................
......>>>>>>>>...>>....<<<<<<<.>>>>>>>...>..>>..>>
>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>..
....>>>..<<<.<<<<....>>>>....>>>.>>.<<.<<<........
..>>>.>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<.
.........>>>..>>>..>....>>>....<<<................
.>>>.......<..............>................<<<<<((
....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>
>>.........<<<[[.....<<<<...<<<.......<<<<...<...<
..<<....<<..<.<.........>.>..>>..>>.>...>..>>>>...
................<<.........<<....<<.......>>..>>..
..>>....<<..<...........<...<<.......>><<<<....>>>
>....>............>..>>...........<<..<<<.<<<.))))
)..>.>>...>>>..>>........<<..<.<.....>>...>>......
....<<<<<..<<...<<<<<<<<..<<<<<<<<...<<<......>>>.
.....>>>>>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>
....>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>.
..>>>>>>>>>.........<<<.<<...<..<.<<<<<<<<<......>
>>>.>>>>>.>..>......<<..]]>>.....>>.....>>>.>>>.<<
<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<
<.<<<<<<..<<.<<<<<<<......<<........>>..........<<
<<<.<....<<<<<........<<.<<<......>>>.>>......>>>>
>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<...
...>>>...>>.>>>....<<<<<.<<<<.....<<<.<<<<<<<.....
..................>>>>..>>>.>>>.....>>>>....<<<<<<
.......>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>..
...>.>>>>>...>>.>>>>>.>>.....<<<.<<<.......<....<.
..>.<<<<<<<........>>>>>>>....>........>>>...>>>..
....<....<<<.<<..........>>.>>>.....>.....>>>>>>..
..<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.
...<..<<.<.<<<<<<<<..<<.<<<.<<<<<<..<<<<<.<...<...
....>...>.>>>>>..>>>>>>.>>>.>>..>>>>>>>>..>.>>...>
.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		M18 H20 K21 R22 Q27 P29 N30 Y48 H50 T52 G69 K71 L74 T76
Binding residue
(residue number reindexed from 1)		M17 H19 K20 R21 Q26 P28 N29 Y47 H49 T51 G68 K70 L73 T75
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum8ove
PubMed37985661
UniProtQ383V7

[Back to BioLiP]