Structure of PDB 8c3a Chain AW Binding Site BS01 |
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| >8c3a Chain AS (length=3229)
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ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugca
ugccgcugcgguuuaccgggccagcaucgguuuggagcggcaggauaaug
gcggaggaauguggcacggcuucugcuguguguuauagccucugacgaua
cugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaa
ugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucua
ugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaagg
ugggggcccauuagggugcaccaucgaccgauccugauguguucggaugg
auuugaguaagagcauagcuguugggacccgaaagauggugaacuaugcc
ugaauagggugaagccagaggaaacucugguggaggcucguagcgguucu
gacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucg
aaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaag
cucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguug
aaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguu
gcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuu
ugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagug
ccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagac
agccggacgguggccauggaagucggaauccgcuaaggaguguguaacaa
cucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugc
uacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcag
gcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggcc
ucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuuga
agacugaaguggggaaagguuccaugucaacagcaguuggacauggguua
gucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuuca
ggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauaugg
auucuucacggcaacguaacugaauguggagacgucggcgugagcccugg
gaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuau
ccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcgucc
ggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucau
gccaagucguacucauaaccgcagcaggucuccaagguuaacagccucua
guugauagaauaauguagauaagggaagucggcaaaauagauccguaacu
ucgggauaaggauuggcucuaaggaucgggcacguuuaacgaucaacuua
gaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauu
gugauggucagaaagugauguugacacaaugugauuucugcccagugcuc
ugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggagu
aacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugac
gcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagc
gaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaaga
cccuguugagcuugacucuaguuugacauugugaaaagacauggagggug
uagaauaagugggagcuucggcgccggugaaauaccacuaccucuauagu
uuuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucua
gcauuaagcccucugggcgauccggguugaagacauugucagguggggag
uuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaaggg
ggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccc
cuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuauc
gauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuacc
acagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuu
uugauucuucgaugucggcucuuccuaucauaccgaagcagaauucggua
agcguuggauuguucacccacuaauagggaacgugagcuggguuuagacc
gucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauagu
aauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugc
ggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggc
ugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccu
gcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagc
aggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcgg
auagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagau
guacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugc
ugagauuaagcucuuguugucugauuugu |
.......................<<<<<<.....<......>......>>
>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>
>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.........
....<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>
>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....<<<<
<..((((((>>>>>..>>>....>..........................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<<...<<<<
......>>>>...>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.
<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.
>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....
>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<
<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<
<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>
>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<
<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.
<<........>>>>.>>>....>>>>>>>>>...<<.......>>.....
.>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<
<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<..
.....>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<
.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<
<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(
((.....<<<<<<.....<<..........<<<.<<<<<<<<<<......
.<<<<<.<<<...<<.........>>...>>>.........<<......>
>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>
.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>
>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>
>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>
><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....
((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>
>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<
<<.....<<<....>>>.....{{<<<<<<...<<<<.<<<<<<<.<<<<
<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....
>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>
>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>
>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>
>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<......
.........>>>>><<.<<<<<<<<<<<...........>>>>>..>>>>
>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<
<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<
....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<
.......>>>>>>........<...........<<<<<.......>>>>>
.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>
....>>....<<<<<........>>>>>....<<<<<..<<<.<<.....
.<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<...<<...
..............<......>...................>>..>>.>>
>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>.......
...}}..<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>
>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<
<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>
>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))...
...<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>
>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>..
.>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>
...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<
<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<
...<<<<<.................>>>>>..<<<<<...<<<<....<<
<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<
<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<
<<.<<<.......<<..........<<<<....>>>>......>>.....
..<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..
..............>>>.>>>>>>..<<<<<<<.............>>..
..<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>
...>>>....>>>>.>>>>>..>>>>>.. |
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| PDB | 8c3a New crystal system to promote screening for new eukaryotic inhibitors |
| Resolution | 3.0 Å |
Binding residue
(original residue number in PDB) | G2 R3 V4 N7 Q8 R9 K10 G11 S14 I15 F16 T17 S18 H19 T20 R21 L22 R23 K24 G25 A26 Y34 R37 H38 Y40 H50 P52 R64 Y67 Y69 K70 L71 R72 G85 F87 Y89 K93 S95 E118 A125 L126 G127 R128 T129 S130 G131 N132 L150 P151 S152 K156 R174 I175 K177 L179 L180 K181 A182 G183 F186 H187 K188 K190 K192 R193 N194 W196 P197 K198 T199 R200 G201 V202 A203 M204 N205 P206 V207 D208 H209 H211 G213 G214 N215 H216 Q217 H218 G220 K221 A222 S223 T224 I225 S226 R227 V230 S231 G232 Q233 K234 A235 G236 I238 A239 A240 R241 R242 T243 G244 L245 L246 |
Binding residue
(residue number reindexed from 1) | G1 R2 V3 N6 Q7 R8 K9 G10 S13 I14 F15 T16 S17 H18 T19 R20 L21 R22 K23 G24 A25 Y33 R36 H37 Y39 H49 P51 R63 Y66 Y68 K69 L70 R71 G84 F86 Y88 K92 S94 E117 A124 L125 G126 R127 T128 S129 G130 N131 L149 P150 S151 K155 R173 I174 K176 L178 L179 K180 A181 G182 F185 H186 K187 K189 K191 R192 N193 W195 P196 K197 T198 R199 G200 V201 A202 M203 N204 P205 V206 D207 H208 H210 G212 G213 N214 H215 Q216 H217 G219 K220 A221 S222 T223 I224 S225 R226 V229 S230 G231 Q232 K233 A234 G235 I237 A238 A239 R240 R241 T242 G243 L244 L245 |
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