Structure of PDB 8ois Chain AV Binding Site BS01

Receptor Information

>8ois Chain AV (length=362) Species: 9606 (Homo sapiens)

LLSSAYVDSHKWEAREKEHYCLADLASLMDKTFERKLPVSSLTISRLIDN
ISSREEIDHAEYYLYKFRHSPNCWYLRNWTIHTWIRQCLKYDAQDKALYT
LVNKVQYGIFPDNFTFNLLMDSFIKKENYKDALSVVFEVMMQEAFEVPST
QLLSLYVLFHCLAKKTDFSWEEERNFGASLLLPGLKQKNSVGFSSQLYGY
ALLGKVELQQGLRAVYHNMPLIWKPGYLDRALQVMEKVAASPEDIKLCRE
ALDVLGAVLKALTSAEKLVEQLDIEETEQSKLPQYLERFKALHSKLQALG
KIESEGLLSLTTQLVKEKLSTCEAEDIATYEQNLQQWHLDLVQLIQREQQ
QREQAKQEYQAQ

Ligand information

>8ois Chain BX (length=14) Species: 9606 (Homo sapiens)

QPPPKPVIVDKHRP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ois Molecular basis of translation termination at noncanonical stop codons in human mitochondria.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): C49 H87 Y90 Y93
• Binding residue (residue number reindexed from 1): C21 H59 Y62 Y65

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0005515 protein binding
• GO:0019843 rRNA binding
• GO:0097177 mitochondrial ribosome binding

Biological Process

• GO:0006417 regulation of translation
• GO:0008283 cell population proliferation
• GO:0032543 mitochondrial translation
• GO:0070131 positive regulation of mitochondrial translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8ois, PDBe:8ois, PDBj:8ois
• PDBsum: 8ois
• PubMed: 37141370
• UniProt: Q92552|RT27_HUMAN Small ribosomal subunit protein mS27 (Gene Name=MRPS27)