Structure of PDB 6vlz Chain AV Binding Site BS01

Receptor Information

>6vlz Chain AV (length=367) Species: 9606 (Homo sapiens)

YLLSSAYVDSHKWEAREKEHYCLADLASLMDKTFERKLPVSSLTISRLID
NISSREEIDHAEYYLYKFRHSPNCWYLRNWTIHTWIRQCLKYDAQDKALY
TLVNKVQYGIFPDNFTFNLLMDSFIKKENYKDALSVVFEVMMQEAFEVPS
TQLLSLYVLFHCLAKKTDFSWEEERNFGASLLLPGLKQKNSVGFSSQLYG
YALLGKVELQQGLRAVYHNMPLIWKPGYLDRALQVMEKVAASPEDIKLCR
EALDVLGAVLKALTSEKLVEQLDIEETEQSKLPQYLERFKALHSKLQALG
KIESEGLLSLTTQLVKEKLSTCEAEDIATYEQNLQQWHLDLVQLIQREQQ
QREQAKQEYQAQKAAKA

Ligand information

>6vlz Chain AA (length=944)

auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugc
aagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaag
gaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagcc
acacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaagu
uuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccacc
gcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuu
uagaucacccccaauaaagcuaaaacucaccugaguuguaaaaaacucca
guugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacaca
auagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaa
accucaacaguuaaaucaacaaaacugcucgccagaacacuacgagccac
agcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagc
cuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagc
cuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcg
caaguacccacguaaagacguuaggucaagguguagcccaugagguggca
agaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaacuu
aagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguug
aacagggcccugaagcgcguacacaccgcccgucacccuccucaaguaua
cuucaaaggacauuuaacuaaaaccccuacgcauuuauauagaggagaca
agucguaacaugguaaguguacuggaaagugcacuuggacgaac

..((((..<<<<<<.)))).<<<<<<.....<<<<<<<<..<.<<<.<<<
..<......>......<<........<<<....<<<.....>>>....>>
>...<<<<....<<<..<<<....>>>.>>>......>>>>.<<...>>.
>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>
>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>
)).......)))..>>>>>.....>>>>>>....<<<((.....<<<<..
<<<<..........<<<<<<......<<<.<<<.<<<......>>>..>>
>.>>>............<<<....>>>>>>>>>.....>>>>...>>>>.
..<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..>..
.....<.<<<<<......))..>>>>>.>.>>>.<<.......<<<<...
.>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<...<<<
<<<<<<<.....<<........>>..........<<<<<<<.......<<
.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.
....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..
>>.>>>>>>>>.....<<<<.....>>>>.......<<<<<.........
>>>>>............>>>>.....<<<<<<<.........>>>>>>>.
....>>>...>>>>>>>>>>.>>.......<<.<...<<<<<<..<<<<<
..<..........<.......>..........>..>>>>>.>>>>>>...
.>.>>.........<<<<<<<<<....>>>>>>>>>........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6vlz Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation.
• Resolution: 2.97 Å
• Binding residue (original residue number in PDB): R63 L65 P66 V67 S68 P99 W102 Y103 R105 R392 E393 Q396
• Binding residue (residue number reindexed from 1): R36 L38 P39 V40 S41 P72 W75 Y76 R78 R347 E348 Q351

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0005515 protein binding
• GO:0019843 rRNA binding
• GO:0097177 mitochondrial ribosome binding

Biological Process

• GO:0006417 regulation of translation
• GO:0008283 cell population proliferation
• GO:0032543 mitochondrial translation
• GO:0070131 positive regulation of mitochondrial translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6vlz, PDBe:6vlz, PDBj:6vlz
• PDBsum: 6vlz
• PubMed: 32737313
• UniProt: Q92552|RT27_HUMAN Small ribosomal subunit protein mS27 (Gene Name=MRPS27)