Structure of PDB 8ove Chain AU Binding Site BS01

Receptor Information
>8ove Chain AU (length=70) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQNAVMFDKETMDKLMKEVPKYKVITPSIISDRLKISVALAGKGLQHLCR
QGLIRLVSCSSKFRVYTRAA
Ligand information
>8ove Chain AA (length=1836) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcgcaggaaucugcgcauggcucauuacau
cagacguaaucugccgccaaaauuuugcgcauuacuggauaacuuggcga
aacgccaagcuaauacaugaaccaaucggacgcucucuuugggacgucca
gcgaaugaaugaaaccaacgccuccggaggcaguaacacucagacguguu
gacucaauucauuccgugcgaaagccgagcugcucggcgucuacugacga
acaacugcccuaucagccagugauggccguguaguggacugccauggcgu
ugacgggagcgggggauuaggguucgauuccggagagggagccugagaaa
uagcuaccacuucuacggagggcagcaggcgcgcaaauugcccaaugucg
aaaaaauacgaugaggcagcgaaaagaaauagagccgaccgugugguugu
uuucaaugggggauacucaaacccauucaauaucgaguaacaauuggagg
acaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauau
uaaugcuguugcuguuaaaggguucguaguugaacugugggccacguagu
guggugccguaccagucccguaccucgacguguuuugacccacgcccucg
uggcccagauacagaaacacgggagcaguucgcaugucaugcaugggcgu
ccgugaauuuuacugugaccaaaaagaugcgaccaaagcaguuugccgac
uugaauuacaaagcaugggauaacgaagcaucagcccugggguuauguug
guuuuagaaguccuugggagauuauggggccgccgcgcggcuucgaauga
aggaggguaguucgggggagaacguacuggugcgucagaggugaaauucu
uagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuu
ccucaaucaagaaccaaaguguggggaucaaagaugauuagagaccauug
uaguccacacugcaaaccaugacacccaugaauuggggagugccucucag
cacguuucuuacuucuucacgcgaaagcuuggagguuacagucucagggg
ggaguacguucgcaagagugaaacuuaaagaaauugacggaauggcacca
caagacguggagcgugcgguuuaauuugacucaacacggggaacuuuacc
agauccggacagggugaggauugacagauggaguucuuucucgauccccu
gaaugguggugcauggccgcuuuuggucgguggagugauuuguuugguug
auuccgucaacggacgagauccaagcugcccaguaggugccgggauuguc
cacacaggacagcauccuucuuuaggccccuucucugcgggauuccuugc
uuuucgcgcaaggugagauuuugggcaacagcaggucugugaugcuccuc
aauguucugggcgacacgcgcacuacaaugucagugagaacaagagucga
cgcucccgcuugaucaaaagagcggggaaaccacggaaucacguagaccc
acuugggaccgaguauugcaauuauuggucgcgcaacgaggaaugucucg
uaggcgcagcucaucaaacugugccgauuacgucccugccauuuguacac
accgcccgucguuguuuccgaugauggugcaauacaggugaucggaccgu
caccgaaaguucaccgauauugcuucaauagaggaagcaaaagucguaac
aagguagcuguaggugaaccugcagcuggaucauuu
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<..>>>...>>.>>......<<........
<<<..<<..<<...<<..<................<<.....<<<<<<..
...>>>>>>......>>..........<<<<<.<<<.....>>>>>>>>.
<<<<<<<<<<....(((((<<<<....>>>>...................
......>>>>>>>>...>>....<<<<<<<.>>>>>>>...>..>>..>>
>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>..
....>>>..<<<.<<<<....>>>>....>>>.>>.<<.<<<........
..>>>.>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<.
.........>>>..>>>..>....>>>....<<<................
.>>>.......<..............>................<<<<<((
....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>
>>.........<<<[[.....<<<<...<<<.......<<<<...<...<
..<<....<<..<.<.........>.>..>>..>>.>...>..>>>>...
................<<.........<<....<<.......>>..>>..
..>>....<<..<...........<...<<.......>><<<<....>>>
>....>............>..>>...........<<..<<<.<<<.))))
)..>.>>...>>>..>>........<<..<.<.....>>...>>......
....<<<<<..<<...<<<<<<<<..<<<<<<<<...<<<......>>>.
.....>>>>>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>
....>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>.
..>>>>>>>>>.........<<<.<<...<..<.<<<<<<<<<......>
>>>.>>>>>.>..>......<<..]]>>.....>>.....>>>.>>>.<<
<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<
<.<<<<<<..<<.<<<<<<<......<<........>>..........<<
<<<.<....<<<<<........<<.<<<......>>>.>>......>>>>
>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<...
...>>>...>>.>>>....<<<<<.<<<<.....<<<.<<<<<<<.....
..................>>>>..>>>.>>>.....>>>>....<<<<<<
.......>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>..
...>.>>>>>...>>.>>>>>.>>.....<<<.<<<.......<....<.
..>.<<<<<<<........>>>>>>>....>........>>>...>>>..
....<....<<<.<<..........>>.>>>.....>.....>>>>>>..
..<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.
...<..<<.<.<<<<<<<<..<<.<<<.<<<<<<..<<<<<.<...<...
....>...>.>>>>>..>>>>>>.>>>.>>..>>>>>>>>..>.>>...>
.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		N44 S78 V79 A80 K84 Q87 C90 R91 C100 S102 K103
Binding residue
(residue number reindexed from 1)		N3 S37 V38 A39 K43 Q46 C49 R50 C59 S61 K62
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum8ove
PubMed37985661
UniProtQ57XX0

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