Structure of PDB 6xu7 Chain AU Binding Site BS01

Receptor Information

>6xu7 Chain AU (length=102) Species: 7227 (Drosophila melanogaster)

SVHRIRITLTSRNVRSLENVCRDLINGAKNQNLRVKGPVRMPTKTLRITT
RKTPCGEGSKTWDRFQMRIHKRIIDLHSPSEIVKKITSINIEPGVEVEVT
IA

Ligand information

>6xu7 Chain B2 (length=1936)

auucugguugauccugccaguaguuauaugcuugucucaaagauuaagcc
augcaugucuaaguacacacgaauuaaaagugaaaccgcaaaaggcucau
uauaucaguuaugguuccuuagaucguuaacaguuacuuggauaacugug
guaauucuagagcuaauacaugcaauuaaaacaugaaccuuaugggacgu
gugcuuuuauuaggcuaaaaccaagcgaucgcaagaucguuauauugguu
gaacucuagauaacaugcagaucguauggucuuguaccgacgacagaucu
uucaaaugucugcccuaucaacuuuugaugguaguaucuaggacuaccau
gguugcaacggguaacggggaaucaggguucgauuccggagagggagccu
gagaaacggcuaccacaucuaaggaaggcagcaggcgcguaaauuaccca
cucccagcucggggagguagugacgaaaaauaacaauacaggacucauau
ccgaggcccuguaauuggaaugaguacacuuuaaauccuuuaacaaggac
caauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaa
uagcguauauuaaaguuguugcgguuaaaacguucguaguugaacuugug
cuucauacggguaguauacuauaccuuuauguauguaagcguauuaccgg
uggaguucuuauaugugaucauauguuccuccuauuuaaaaaccugcauu
agugcucuuaaacgaguguuauugugggccgguacuauuacuuugaacaa
auuagagugcuuaaagcaggcuucaaaugccugaauauucugugcauggg
auaaugaaauaagaccucuguucugcuuucauugguuuucagaucaagag
guaaugauuaauagaagcaguuugggggcauuaguauuacgacgcgagag
gugaaauucuuggaccgucguaagacuaacuuaagcgaaagcauuugcca
aagauguuuucauuaaucaagaacgaaaguuagagguucgaaggcgauca
gauaccgcccuaguucuaaccauaaacgaugccagcuagcaauugggugu
agcuacuuuuauggcucucucagucgcuuccgggaaaccaaagcuuuuug
ggcuccgggggaaguaugguugcaaagcugaaacuuaaaggaauugacgg
aagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggg
aaaacuuaccaggucgaacauaaguguguaagacagauugauagcucuuu
cucgaaucuaugggugguggugcauggccguucuuaguucguggagugau
uugucugguuaauuccgauaacgaacgagacucaaauauauuaaauagau
aucuucaggauuauggugcugaagcuuauguagccuucauuauuguguuu
gaauguguuuauguaaguggagccguaccuguugguuugucccauuauaa
ggacacuagcuucuuaaauggacaaauugcgucuagcaauaaugagauug
agcaauaacaggucugugaugcccuuagauguccugggcugcacgcgcgc
uacaaugaaaguaucaacguguauuuccuagaccgagagguccggguaaa
ccgcugaaccacuuucaugcuugggauugugaacugaaacuguucacgau
gaacuuggaauucccaguaagugugagucauuaacucgcauugauuacgu
cccugcccuuuguacacaccgcccgucgcuacuaccgauugaauuauuua
gugaggucuccggacgugaucacugugacgccuugcguguuacgguuguu
ucgcaaaaguugaccgaacuugauuauuuagaggaaguaaaagucguaac
aagguuuccguaggugaaccugcggaaggaucauua

...<<<<..{.(((..>>>><<<<..<<<<<...<.<<.........<<<
.<<<..<<....<<.....<.........>....>>.>>......<<...
.....<<<.<<<..<<....<<<...............<<.....<<.<<
.......>>.>>......>>...........<<<<............>>>
>.<<<.<<<<<.....(((...{...<<<<....>>>>.........<..
.....>..>>>>>.>.>>...<.<<..............>>>.....>>>
...>>>>>.>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>
>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..
........>>>.>>.<.<<....>>.>...>>>>>>.........<<<..
..<<<.....>>>..>>>......>>.>.....<<<<..<<<..<<....
..>>...>>>..>.>>>........<..............>.........
...<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>
..>>>>>.>>>>.........<<<[[.....<<<<...<<<.<<.....<
<<<.................................>>>>.....<<<<.
..................................................
.............................>>>>...<<<<<<.<<.....
..<<...<.......>.<<<.........>>>...>>.......>>.>>.
.>>>>..........................}....)))...........
.......>>....<<<<....<<...<<<<..<<..<<<<<<<<.<.<<<
......>>>.....>>>>>>>>>..>>.......<<....>>...>>>>.
..>>..>.>>>...>>>...>>>>....<<<<<<....<...<<<<.<..
...>.>>>>...>.>>>>>>..........<<<.<<.<<<.<<<<<<.<.
.<<<<......>>>>.>.>>>>>>.>>>...<<..]]>>...>>......
>>>.>>>.<<.......<.<<....>>.>.....>>...))).}......
<<.<<<...<<..<<<<<..<<<.<<<<........<<........>>..
........<<<<<..................<<..<<........>>..>
>..............<<.<<<..<<.<<<<<.....<<<.<..<......
>....<<<......>>>....>.>>>....<<<......<<<<...<<..
.<.....<<....<<..........<<<<<<...................
..........>>>>>>.......>>..>>.....>...<<..........
..>>.....>>...>.>>>..............................>
>>.....>>.>>>.....>>>>>>>.......>>>>>......>>>>.>>
>.....<<<<<.........<.....<<<.<<<<....>>>>.>>>....
>..........>>>>>......<....<....<..........>....>.
...>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>
....>>>.>>..........<..<<.<..<<<<.<<....<<<<.<<<.<
<<..<<<<..<....<<<<.<<<...<<<.........>>>..>..>>..
>>>>....>..>>>>..>>>.>>>.>>>>...>>.>>>>...>.>>...>
......<<<<<<<<....>>>>>>>>..........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6xu7 Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching.
• Resolution: 4.9 Å
• Binding residue (original residue number in PDB): S18 V19 R21 E35 R51 K53 G54 P55 R57 M58 P59 R64 T66 K69 T70 C72 E74 G75 S76 K77 W79 R85 R89 H94
• Binding residue (residue number reindexed from 1): S1 V2 R4 E18 R34 K36 G37 P38 R40 M41 P42 R47 T49 K52 T53 C55 E57 G58 S59 K60 W62 R68 R72 H77

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit

External links

• PDB: RCSB:6xu7, PDBe:6xu7, PDBj:6xu7
• PDBsum: 6xu7
• PubMed: 34283226
• UniProt: P55828|RS20_DROME Small ribosomal subunit protein uS10 (Gene Name=RpS20)