Structure of PDB 5t2c Chain AU Binding Site BS01

Receptor Information
>5t2c Chain AU (length=143) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDEN
WFYTRAASTARHLYLRGGAGVGSMTKIYGGRQRNGVMPSHFSRGSKSVAR
RVLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAANKK
Ligand information
>5t2c Chain AA (length=1742) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaa
cugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucg
cgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggcc
gaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuau
caacuuucgaugguagucgccgugccuaccauggugaccacgggugacgg
ggaaucaggguucgauuccggagagggagccugagaaacggcuaccacau
ccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggaggu
agugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaa
ugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucugg
ugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcu
gcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgcc
ucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaa
gcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggacc
gcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggac
ggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggc
gcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaauca
agaacgaaagucggagguucgaagacgaucagauaccgucguaguuccga
ccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgc
cgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguauggu
ugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggagugg
agccugcggcuuaauuugacucaacacgggaaaccucacccggcccggac
acggacaggauugacagauugauagcucuuucucgauuccguggguggug
gugcauggccguucuuaguugguggagcgauuugucugguuaauuccgau
aacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcgguc
ggcgucccccaacuucuuagagggacaaguggcguucagccacccgagau
ugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgc
gcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggg
uaacccguugaaccccauucgugauggggaucggggauugcaauuauucc
ccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauu
aagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugg
uuuagugaggcccucggaucggccccgccggggucggcccacggcccugg
cggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagu
cguaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<..[.((((.>>>><<<.<<<<<<.....<<.........<<<.
<<<..<<....<......<..........>.....>.>>......<<...
.....<<<......<<....<<<....................<.<....
<<.<<<.....>>>.>>......>>..........<<<....<<<<....
.>>.>>....>>>.<...<<<<<...<......>..>>>>>........>
..<<<<..<<........>>.>>>>....>>>...>>....>>>.<<<..
..<<<.....<<<<<<.........>>>>>>.>>>......>>>...<<<
.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<
<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>
......>>.......<<.....<..............>.......>>...
...<<..<...........>..>>.........<<<<<<<........[.
.....((..>>))........]...>>>>>..>>>>>>.>>>........
.<.<((.....<.<<...<<<.<<..........................
......................<<<.<<.<.......<<...<.......
>..<<.........>.>...>>......>.>>...>>>.......<<...
..<<<<..................>.>>>....>>....>>....<<<<<
<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>
>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>..
.>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>
>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>
>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<
......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..
<<..<<<<.........<........>...........<<<<<.......
<<<<........<<..<<........>>..>>......>>>>....<<..
.<.....<<<<<<....<<<.<<<<<....>>>...<<........>>..
.>>.>>>....<<....<...<<<....<.<..........<........
>..........>.>...>>>..>.....<<<<<.....>>>>>.......
..>>....>>>.>>>.......>..>>.......>>>>>......>>>>.
.>>........<<.........<.......<<..<<<<....>>>>..>>
....>..........>>.........<.....<<<<<..........>>>
>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>....
..>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<
<<.<<<...<<<.<<...<<<<<<<.........................
.>>...>>>>>...>>.>>>...>>>.>>>>>>>>...>>.>>>>...>.
>>...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5t2c Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		P2 G3 V4 K7 Q11 Q12 A40 K41 K43 E44 L45 P47 S59 R62 R67 A70 G71 V72 S74 K77 R82 R84 N85 V87 M88 P89 S90 F92 K97 R101 Q105 E108 K115 G119 G120 R121 Q128 R129 D132 R133
Binding residue
(residue number reindexed from 1)		P1 G2 V3 K6 Q10 Q11 A39 K40 K42 E43 L44 P46 S58 R61 R66 A69 G70 V71 S73 K76 R81 R83 N84 V86 M87 P88 S89 F91 K96 R100 Q104 E107 K114 G118 G119 R120 Q127 R128 D131 R132
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0017134 fibroblast growth factor binding
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181 cytoplasmic translation
GO:0002548 monocyte chemotaxis
GO:0006364 rRNA processing
GO:0006412 translation
GO:0007000 nucleolus organization
GO:0030218 erythrocyte differentiation
GO:0030490 maturation of SSU-rRNA
GO:0031640 killing of cells of another organism
GO:0042274 ribosomal small subunit biogenesis
GO:0050829 defense response to Gram-negative bacterium
GO:0060265 positive regulation of respiratory burst involved in inflammatory response
GO:0060266 negative regulation of respiratory burst involved in inflammatory response
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5t2c, PDBe:5t2c, PDBj:5t2c
PDBsum5t2c
PubMed27752045
UniProtP39019|RS19_HUMAN Small ribosomal subunit protein eS19 (Gene Name=RPS19)

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