Structure of PDB 4v8m Chain AU Binding Site BS01

Receptor Information

>4v8m Chain AU (length=85)

KKAAKKWSKGRTREALQNAVMFDKETMDKLMKEVPKYKVITPSIISDRLK
ISVALAGKGLQHLCRQGLIRLVSCSSKFRVYTRAA

Ligand information

>4v8m Chain AA (length=2227)

gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcauugcaggaaucugcgcauggcucauua
caucagacguaaucugccgccaaaauuuugcggucuccgcauuacuggau
aacuuggcgaaacgccaagcuaauacaugaaccaaucggacgcucucuuu
uucuaugucgcggcuuguguuuacgcacuugucguggcgaugagacgucc
agcgaaugaaugaaauuagaaccaacgccuccacccgggggcaguaacac
ucagacguguugacucaauucauuccgugcgaaagccgagccuuuuugcu
cggcgucuacugacgaacaacugcccuaucagccagugauggccguguag
uggacugccauggcguugacgggagcgggggauuaggguucgauuccgga
gagggagccugagaaauagcuaccacuucuacggagggcagcaggcgcgc
aaauugcccaaugucgaaaaaauacgaugaggcagcgaaaagaaauagag
ccgaccgugcccuagugcaugguuguuuucaaugggggauacucaaaccc
auccaauaucgaguaacaauuggaggacaagucuggugccagcacccgcg
guaauuccagcuccaaaagcguauauuaaugcuguugcuguuaaaggguu
cguaguugaacugugggccacguaguuuugugccgugccagucccgucca
ccucggacguguuuugacccacgcccucguggcccgugaacacacucaga
uacaagaaacacgggagcgguuccuccucacuuucacgcaugucaugcau
gcgagggggcguccgugaauuuuacugugaccaaaaaagugcgaccaaag
cagucugccgacuugaauuacaaagcaugggauaacgaagcaucacaccg
uuucggcuuuuguugguuuuagaaguccuugggagauuauggggccgcgu
gccuugggucgguguuucgugucucauuuuuguggcgcgcacauucggcu
cuucgugauguuuuuuuacauucauugcgacgcgcggcuuccaggaauga
aggaggguaguucgggggagaacguacuggugcgucagaggugaaauucu
uagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuu
ccucaaucaagaaccaaaguguggggaucaaagaugauuagagaccauug
uaguccacacugcaaaccaugacacccaugaauuggggaacaucauuggg
ugcccguguggcggccuuuugugccgacccucggccccaauuuauuuauc
aauuuacgugccuauucuaucacccccgguucccucuuuugagguucuuc
cgggguuuuuuacgggaauauccucagcacguuucuuacuucuucacgcg
aaagcuuggagguuacagucucaggggggaguacguucgcaagagugaaa
cuuaaagaaauugacggaauggcaccacaagacguggagcgugcgguuua
auuugacucaacacggggaacuuuaccagauccggacagggugaggauug
acagauggaguguucuuucucgauccccugaaugguggugcauggccgcu
uuuggucgguggagugauuuguuugguugauuccgucaacggacgagauc
caagcugcccaguaggugccgggauugcagucccuccggcggggauuuuu
uccccaacgguggucgucauccuucuuuuuacaggccccuucucugcggg
auuccuugcuuuucgcgcaaggugagauuuugggcaacagcaggucugug
augcuccucaauguucugggcgacacgcgcacuacaaugucagugagaac
aagaguccgagcggcacuucacaaugucgcucccgcuugaucaaaagagc
ggggaaaccacggaaucacguagacccacuugggaccgaguauugcaauu
auuggucgcgcaacgaggaaugucucguaggcgcagcucaucaaacugug
ccgauuacgucccugccauuuguacacaccgcccgucguuguuuccgaug
auggugcaauacaggugaucggaccgucgcucgucucgggcgaccgaaag
uucaccgauauugcuucaauagaggaagcaaaagucguaacaagguagcu
guaggugaaccugcagcuggaucauuu

...<<<<..{.[[[[.>>>><<<..<<<<<<....<...........<<.
.<<<..<<..........<<<.....>>>......>>......<<.....
...<<<..<...<<....<..<......<<<<<...>>>>>....<<...
..<<<<<<.....>>>>>>......>>..........<<<<<.<<.....
...........<<<..<<<......>>>..>>>..........>>>>>>>
...<<<<<<<<........(((((..<<<<........>>>>........
.................>>>>>>>>.........<<<<<<<......>>>
>>>>...>..>...>>.>..>>>.<<<....<<.....<<<<<.<.....
....>.>>>>>.>>......>>>..<<<.<<.<....>.>>....>>>.>
>.<<.<<<..........>>>.>>.<<<......>>>...>>>.>>....
.....<<<....<<<..........>>>..>>>........>.....<<<
..<<<<<<<<......>>>>>>>>...>>>......<.............
........>..........<<<<<((......<<<..........))...
.......>>>.>>>>>..>>>>>>.>>>.........<<<[[.....<<<
<...<<<.......<<<<<<<.......................<<<<..
.....>>>>...................>>>>>>>...............
.....<<<.<<<<<<......<<<.............<<<<<<...>>>>
>>...>>>...>>>>>>..>>>.<.<<<<.<...................
..<........>............>>>>>...>.................
<....<<<<<...)))))...>>>>>.....>.......<<<<<<<<<<<
.<<..<......<<<<.................>>>>....>....>>..
..<<<<<<<<............>>>>>>>>.>>>>>>.>>>>>.......
....<<...<.<<...<<<<<..<<.<<<<<<<<....<........>..
.....>>>>>>>.>>>........<<....>>..>>>>>..>>.>....>
>...>>>...>>>>...<<<<<<<..<.<...<<<<.........>>>>.
..>>>>>>>>>.........<<<.<<....<..<<<<<<<<...<<<<<<
.<<<.<.<.<<<<<<.......>>>>.>>>.>>>>>>>>>>..<<<....
>>>....<<<<..<<<<<.....<<<<<<...<<<<....>>>>.....>
>>>>>.........>>>>>.......>>>>>>>>>>>>..>......<<.
.]]>>.....>>.....>>>.>>>.<<<......<<<<....>>>>....
>>>..]]]].}<<<<<.<<<<<<<..<<..<<<<<..<<.<<<<<.....
...<<........>>..........<<<<<......<<<<<........<
<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.
....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<
<<..<<.....<........<<<<.......<<..<<<..<<<<<.....
>>>>>..>>>.>>......>>>>....................>...>>.
...<<<<<<.......>>>>>>........>>>>.....>>.>>>.....
>>>>>>>.......>>>>>......>>>>>.>>.....<<<.<<......
.........<<<<<<<........>>>>>>>....<<<<.<<....>>.>
>>>................>>.>>>...........<<<.<<........
..>>.>>>...........>>>>>.....<<<<<<<.........>>>>>
>>......>>...>>>>>>>>>>.>>.......<<...<<<<<<<...<<
.<<<.<<<<<<..<<<<......<.<<<<<<<<...>>>>>>>>.>....
..>>>>..>>>>>>.>>>.>>...>>>>>>>....>>.........<<<<
<<<<<....>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4v8m High-Resolution Cryo-Electron Microscopy Structure of the Trypanosoma Brucei Ribosome.
• Resolution: 5.57 Å
• Binding residue (original residue number in PDB): K27 K28 K31 K32 W33 S34 K35 R37 N44 A45 V46 I77 S78 A80 L81 K84 S102 K103
• Binding residue (residue number reindexed from 1): K1 K2 K5 K6 W7 S8 K9 R11 N18 A19 V20 I51 S52 A54 L55 K58 S76 K77

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v8m, PDBe:4v8m, PDBj:4v8m
• PDBsum: 4v8m
• PubMed: 23395961
• UniProt: Q57XX0