Structure of PDB 8wq2 Chain AS4P Binding Site BS01

Receptor Information
>8wq2 Chain AS4P (length=166) Species: 330779 (Sulfolobus acidocaldarius DSM 639) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPRKSKKKWMGPSHPWIKINLGKEQILIGKYGLRNKKEIWIAQTMIRNFR
HQARSLLALPPAERNIREKQLIQKLYRMGILEKDNSTLDDILSLTEENYL
ERRLQTIVYKKGLARTIYQARQLITHGHIAISGRKVTSPGYVVLRGEEDL
IDYYPTSPFKQNPPSQ
Ligand information
>8wq2 Chain A16S (length=1328) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auuccgguugauccugccggacccgaccgcuaucgggguagggauaagcc
augggagucuuacacucccggguaagggaguguggcggacggcugaguaa
cacguggcuaaccuacccucgggacggggauaaccccgggaaacugggga
uaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcu
auaggcuauuucccguuuguagccgcccgaggauggggcuacggcccauc
aggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccg
uggaagcgggagccuccaguugggcacugagacaagggcccaggcccuac
ggggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgc
uaccccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcgggg
gaauaagcggggggcaagucuggugucagccgccgcgguaauaccagcuc
cgcgaguggucggggugauuacugggccuaaagcgccuguagccggccca
ccaagucgccccuuaaaguccccggcucaaccggggaacugggggcgaua
cuggugggcuagggggcgggagaggcgggggguacucccggaguaggggc
gaaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuag
aacgcgcccgacggugagaggcgaaagccgggggucccggcuguaaacga
ugcgggcuaggugucgaguaggcuuagagccuacucggugccgcagggaa
gccguuaagcccgccgccuggggaguacggucgcaagacugaaacuuaaa
ggaauuggcgggggagcaccacaagggguggaaccugcggcucaauugga
gucaacgccuggaaucuuaccgggggagaccgcaguaugacggccaggcu
aacgaccuugccugacucgcggagaggaggugcauggccgucgccagcuc
guguugugaaauguccgguuaaguccggcaacgagcgagacccccacccc
uaguugguauucuggacuccgguccagaaccacacuagggggacugccgg
cguaagccggaggaaggagggggccacggcaggucagcaugccccgaaac
ccgggccgcacgcggguuacaauggcagggacaacgggaugcuaccucga
aagggggagccaauccuuaaacccugccgcaguugggaucgagggcugaa
acccgcccucgugaacgaggaaucccuaguaaccgcgggucaacaacccg
cggugaauacgucccugcuccuugcaca
...<<<<..[..(((.>>>>.<<<<<<<.......<<<.<<......<<<
.<<<..<<<..<<<<<<<<......>>>>>>>>>>>......<<..<...
..<<<<<<<..<<...<<<<<<..<<<<<....<<<<........>>>>.
....>>>>>...<<<<<<<...<<......>>..>>>>>>>.....<<<<
<<................>>>>>>..>>>>>>..>>>>>>>>>.<<<...
.<<...<<<<<<<.........>>>>>>>.>>......>>>..<<<<<<<
<....>>>>...>>>>>>>.<<<<<............>>>>>.<<<<...
.>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>
>..>>>....<<<<<.....>>>>>...<<<<<<<.........>>>>>>
>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>
>>>....>>>>>>>..........<<<((.....<<<<...<<<.<<<<<
<<.<<..<<<<<......<<<<<<<.....>>>>>>>....>>>>>....
>>>>>>>>>...<<<<<<.....<<<<<<<<<<.<<<<<<.....<<...
.....>>........>>>>>>.>>>.......<<....>>.>>>>>>>..
..>>>.>>>...>>>...>>>>....<<<<<<...>>>>>>.........
.<<<<<<..<<<.<<<<<<<<<<.....>>>>>>>>>>.>>>...<<..)
)>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)
))..]....<..<<<<<<...<.<<<<<...<<<<<<<<<<......<<.
.......>>..........<<<<......<<..........<.<.<<<..
.....>>>.>.>........>>...<<.<<...<<<<<<<<.....<<<<
<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<
<<...<....<..<<<<....>>>>.>.....>..>>>>>>.....<<<<
<....>>>>>........>>>>>.....>>.>>>...>>>.>>>>.....
>>>>...>>.>>>>>>>>.....<<<<<<<......<<..<<..<<<...
...>>>..>>....>>.....>>>>>>>......<....<<<<<<<....
....>>>>>>>....>......>>>>>....<<<<<<<<.......>>>>
>>>>......>....>>>>>>.>.....
Receptor-Ligand Complex Structure
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PDB8wq2 Structural basis of translation inhibition by a valine tRNA-derived fragment
Resolution4.1 Å
Binding residue
(original residue number in PDB)		D3 P4 R5 K6 K8 K9 K10 M12 S15 H16 P17 W18 R36 N37 K38 K39 R49 N50 H53 Q72 K76 Q121 H128 R136 K137 V138 T139 S140 P141 P160 S167 Q168
Binding residue
(residue number reindexed from 1)		D1 P2 R3 K4 K6 K7 K8 M10 S13 H14 P15 W16 R34 N35 K36 K37 R47 N48 H51 Q70 K74 Q119 H126 R134 K135 V136 T137 S138 P139 P158 S165 Q166
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0043226 organelle
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wq2, PDBe:8wq2, PDBj:8wq2
PDBsum8wq2
PubMed38599770
UniProtP39467|RS4_SULAC Small ribosomal subunit protein uS4 (Gene Name=rps4)

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